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首页> 外文期刊>Environmental toxicology and chemistry >The Subacute Toxicity of Perfluorooctane Sulfonate and/or Perfluorooctanoic Acid and Legacy Aqueous Film-Forming Foams to Japanese Quail (Coturnix japonica) Chicks
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The Subacute Toxicity of Perfluorooctane Sulfonate and/or Perfluorooctanoic Acid and Legacy Aqueous Film-Forming Foams to Japanese Quail (Coturnix japonica) Chicks

机译：全氟辛烷磺酸盐和/或全氟辛酸和遗留含水成膜泡沫的亚急性毒性与日本鹌鹑（Coturnix japonica）雏鸡

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As part of an effort to develop avian ecotoxicity information for poly- and perfluoroalkyl substances (PFAS) including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) associated with aqueous film-forming foam (AFFF) used by the Department of Defense, the subacute toxicity of PFOS, PFOA, PFOS + PFOA, 3M AFFF, and Ansul AFFF to Japanese quail (Coturnix japonica) chicks was determined. Ten-day-old Japanese quail were administered treated feed for 5 d and then fed untreated feed for 18 d. Analyzed concentrations of PFOS, PFOA, and PFOS + PFOA ranged from 62 to 1955, 162 to 1208, and 43 + 45 to 296 + 292 mg kg feed(-1). Analyzed concentrations of PFOS in feed containing the 3M AFFF ranged from 73 to 1399 mg kg feed(-1), and formulated concentrations of 6:2 fluorotelomer thioamido sulfonate in feed containing the Ansul AFFF ranged from 9 to 1118 mg kg feed(-1). Average daily doses resulting in 50% mortality at day 5 were 38 (34-43), 68 (63-74), 55 (51-59), and 130 (103-164) mg PFOS, PFOA, PFOS + PFOA, and PFOS in 3M AFFF kg body weight(-1) d(-1). Ansul AFFF did not result in any mortalities. Dietary concentrations resulting in 50% mortality at day 5 were 351 (275-450), 496 (427-575), 398 (339-468), and 467 (390-559) mg PFOS, PFOA, PFOS + PFOA, and PFOS in 3M AFFF kg feed(-1). Environ Toxicol Chem 2020;00:1-16. (c) 2020 SETAC
机译：作为开发包括全氟辛烷磺酸盐（PFA）和与国防部使用的含水成膜泡沫（AFFF）相关的全氟辛酸酯（PFA）和全氟辛酸（PFOA）的努力开发禽生毒性信息的一部分。确定了PFO，PFOA，PFOS + PFOA，3M AFFF和ANSULFOT的毒性，确定了日本鹌鹑（COTURNIX Japonica）雏鸡。将十天古老的日本鹌鹑用于5天的治疗饲料，然后加入18天的未处理进料。分析浓度的PFO，PFOA和PFOS + PFOA的范围为62至1955,62至1208和43 + 45至296 + 292mg kg饲料（-1）。分析含有3M亚胺的饲料中的PFO的浓度范围为73至1399mg kg进料（-1），并配制浓度为6：2含氟甲酰胺硫酸盐，含有Ansul Afff的饲料中的9-1118mg kg Feed（-1 ）。在第5天导致50％死亡率的平均每日剂量为38（34-43），68（63-74），55（51-59）和130（103-164）Mg PFO，PFOA，PFOS + PFOA和PFOS 3M AFFF KG体重（-1）D（-1）。 ANSUL AFFF没有导致任何死亡率。第5天导致50％死亡率的膳食浓度为351（275-450），496（427-575），398（339-468）和467（390-559）Mg PFOS，PFOA，PFOS + PFOA和PFOS在3M AFFF kg饲料（-1）中。环境毒素化学2020; 00：1-16。 （c）2020 Setac

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