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首页> 外文期刊>Environmental toxicology and chemistry >Sublethal Effects of Dermal Exposure to Poly-and Perfluoroalkyl Substances on Postmetamorphic Amphibians
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Sublethal Effects of Dermal Exposure to Poly-and Perfluoroalkyl Substances on Postmetamorphic Amphibians

机译：真皮暴露在骨折两栖动物上的多种和全氟烷基物质的亚致致盲作用

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Studies of the toxicity of poly- and perfluoroalkyl substances (PFAS) on amphibians, especially after metamorphosis, are limited. We examined effects of dermal PFAS exposure (30 d) on survival and growth of juvenile American toads (Anaxyrus americanus), eastern tiger salamanders (Ambystoma tigrinum), and northern leopard frogs (Rana pipiens). Chemicals included perfluorooctanoic acid, perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and 6:2 fluorotelomer sulfonate (6:2 FTS) at 0, 80, 800, or 8000 ppb on a moss dry weight basis. Exposure to PFAS influenced final snout-vent length (SVL) and scaled mass index (SMI), a measure of relative body condition. Observed effects depended on species and chemical, but not concentration. Anurans exposed to PFOS, PFHxS (frogs only), and 6:2 FTS demonstrated reduced SVL versus controls, whereas salamanders exposed to 6:2 FTS showed increased SVL. Frogs exposed to PFHxS and 6:2 FTS and toads exposed to PFOS had increased SMI compared to controls; salamanders did not demonstrate effects. Concentrations of 6:2 FTS in substrate decreased substantially by 30 d, likely driven by microbial action. Perfluorooctane sulfonate had notable biota-sediment accumulation factors, but was still 1. Although a no-observable-effect concentration could not generally be determined, the lowest-observable-effect concentration was 50 to 120 ppb. Survival was not affected. The present study demonstrates that PFAS bioaccumulation from dermal exposures and sublethal effects are dependent on species, chemical, and focal trait. Environ Toxicol Chem 2020;00:1-10. (c) 2020 SETAC
机译：对两栖动物聚和全氟烷基物质（PFAS）的毒性的研究，特别是变态后，被限制。我们检查了真皮PFAS曝光（30 d）对生存和少年美国蟾蜍生长的影响（Anaxyrus美洲），东部虎纹钝口螈（Ambystoma螈），以及豹蛙（蛙蚊）。化学品包括全氟辛酸，全氟辛烷磺酸（PFOS），全氟己烷磺酸（PFHxS），和6：2的氟化调聚物磺酸盐（6:2 FTS）在0，80，800，或8000 ppb的苔藓干重为基础。暴露于PFAS影响最终吻排泄孔长度（SVL）和缩放的质量指数（SMI），相对体状态的测量值。观察到的效果取决于品种和化学，但不集中。暴露于全氟辛烷磺酸无尾两栖类，PFHxS（仅青蛙）和6：2个FTS表明降低的SVL相对于对照，而山椒暴露于6:2 FTS显示增加SVL。暴露于PFHxS和6青蛙：2个FTS和蟾蜍暴露于全氟辛烷磺酸具有增加SMI与对照组相比;蝾螈没有表现出效果。的6个浓度：2个FTS在基板30 d，容易通过微生物作用驱动大幅下降。全氟辛烷磺酸具有显着的生物沉积物积累因素，但仍<1。尽管没有观察不到效果的浓度通常无法确定，最低可观察到的效果的浓度为50〜120 ppb的。生存并没有受到影响。目前的研究表明，从皮肤暴露和亚致死效应PFAS生物蓄积性取决于品种，化学和焦点特质。 ENVIRON毒理学化学2020; 00：1-10。 （c）2020 Setac

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