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首页> 外文期刊>Environmental toxicology and chemistry >Patterns in Serum Toxicokinetics in Peromyscus Exposed to Per‐ and Polyfluoroalkyl Substances
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Patterns in Serum Toxicokinetics in Peromyscus Exposed to Per‐ and Polyfluoroalkyl Substances

机译：血清毒物动脉内的术治血清和聚氟烷基物质的模式

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Per- and polyfluoroalkyl substances (PFAS) are compounds manufactured for use in paints, cleaning agents, fire suppressants, nonstick cookware, food containers, and water-resistant products. Concerns about PFAS stem from their ubiquitous presence in the environment, persistence, and variable/uncertain bioaccumulation and toxicity. In the present study, 5 perfluoroalkyl acids and one polyfluoroalkyl substance were administered to white-footed mice (Peromyscus leucopus) to elucidate the kinetics of each chemical over 28 d of exposure. Perfluorooctanoate, perfluorohexane sulfonate (PFHxS), and perfluorobutane sulfonate were administered to male and female mice via drinking water. Perfluorooctane sulfonate, perfluorononanoate, 6:2 fluorotelomer sulfonate, and PFHxS were administered to male and female mice via oral gavage. Blood samples collected after 14 or 21 and 28 d of exposure were analyzed for individual PFAS concentrations via liquid chromatography-tandem mass spectrometry. In general, a plateau in serum concentration in this toxicity test-relevant timeline depended on interactions between 1) the type of PFAS (i.e., perfluoroalkyl sulfonic acids [PFSAs] vs perfluoroalkyl carboxylic acids [PFCAs] vs polyfluorinated), 2) continuous versus bolus dosing, and 3) to a lesser extent, sex. Specifically, PFCAs were detected at higher concentration in females than males, whereas PFSAs were generally detected at similar levels across sex. An exception occurred when PFHxS yielded higher serum levels in males than females through bolus, but not continuous, dosing. Type of PFAS had the largest impact on serum concentrations, whereas sex had the lowest. As such, future work on the toxicokinetics of PFAS in common ecological receptors would be valuable to further explore these patterns. Environ Toxicol Chem 2021;00:1-13. (c) 2021 SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
机译：（多氟烷基物质（PFAs）是制造用于涂料，清洁剂，防火剂，非克利福炉，食品容器和防水产品的化合物。对PFAS的担忧源于环境，持续性和可变/不确定生物累积和毒性中的普遍存在。在本研究中，将5个全氟烷基酸和一种聚氟烷基物质施用于白脚小鼠（Peromyscus Leucopus），以阐明每种化学物质的动力学超过28天暴露。通过饮用水施用全氟辛酸酯，全氟己烷磺酸盐（PFHX）和全氟丁烷磺酸盐和雌性小鼠。全氟辛烷磺酸盐，全氟丙酯，6：2氟羧酸磺酸盐和PFHX通过口服饲喂给雄性和雌性小鼠。通过液相色谱 - 串联质谱法分析14或21和21和21d暴露后收集的血液样品。通常，在这种毒性测试相关时间表中的血清浓度的平台依赖于1）的相互作用，PFA的类型（即全氟烷基磺酸[PFSAs]与全氟烷基羧酸[PFCAs] Vs多氟化），2）连续与推注一起给药，3）在较小程度上，性别。具体而言，在女性的较高浓度下检测PFCA比男性更高，而PFSA通常在性别的类似水平下检测到。当PFHXs在雄性中产生更高的血清水平，而不是通过推注而不是连续，给药。 PFA的类型对血清浓度的影响最大，而性别最低。因此，在共同的生态受体中，未来的PFAS毒性学的工作将有助于进一步探索这些模式。环境毒素化学2021; 00：1-13。 （c）2021 Setac。本文为美国政府员工贡献，他们的工作是美国的公共领域。

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