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Sublethal Effect Concentrations for Nonpolar Narcosis in the Zebrafish Embryo

机译：Zebrafish胚胎中非极性麻醉的止骨效应浓度

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Nonpolar narcosis, also known as baseline toxicity, has been described as the minimal toxicity that an organic chemical may elicit based on its lipophilicity. Although lethal effects of narcosis-inducing chemicals (NICs) have been thoroughly investigated, knowledge of sublethal effects is still very limited. We investigated the effects of 3 well-known NICs (phenanthrene, 1,3,5-trichlorobenzene, and pentachlorobenzene) on a variety of organismal endpoints (malformations, swim bladder inflation, respiration, heart rate, swimming activity, and turning angles), which can be plausibly linked to narcosis in zebrafish embryos. Baseline toxicity recorded as mortality is typically observed in similar exposure ranges in a wide variety of species including fish, corresponding to a chemical activity range between 0.01 and 0.1. In the present study, we found that sublethal effects occurred at concentrations approximately 5 times below lethal concentrations. Altered swimming activity and impaired swim bladder inflation were the most sensitive endpoints occurring at exposure levels below the generally accepted threshold for baseline toxicity for 2 out of 3 compounds. Overall, most effective exposure levels across the sublethal endpoints and compounds did fall within the range typically associated with baseline toxicity, and deviations were generally limited to a factor 10. Although there could be benefit in adding sublethal endpoints to toxicity tests, such as the fish embryo acute toxicity (FET) test, based on the present sublethal endpoints and available evidence from our and other studies, the underestimation of toxicity as a result of the sole assessment of mortality as an endpoint in an FET test may be limited for narcosis. Environ Toxicol Chem 2021;00:1-11. (c) 2021 SETAC
机译：非极性麻醉剂，也称为基线毒性，已被描述为有机化学物质可以根据其亲脂性引发的最小毒性。虽然已经进行了彻底调查了麻醉剂诱导化学品（NIC）的致命作用，但对核心作用的了解仍然非常有限。我们研究了3名众所周知的NIC（菲苯乙烯，1,3,5-三氯苯和五氯苯）对各种有机体终点（畸形，游泳膀胱通胀，呼吸，心率，游泳活动和转向角）的影响，这可以合理地与斑马鱼胚胎的麻醉有关。作为死亡率的基线毒性通常在类似的曝光范围内观察到包括鱼类的各种物种，对应于0.01和0.1之间的化学活性范围。在本研究中，我们发现在致命浓度以下约5倍的浓度下发生核心作用。改变的游泳活性和游泳膀胱受损的血液膨胀是在3低于3种化合物中的基线毒性的通常接受的阈值下发生的最敏感的终点。总体而言，过度止吐终点和化合物的最有效的暴露水平落在通常与基线毒性相关的范围内，并且偏差通常限于因子10。虽然可以有益于向毒性测试添加亚偶终点，例如鱼类基于本发明的核对终点和来自我们和其他研究的可用证据，胚胎急性毒性（FET）试验，由于唯一的毒性，由于FET试验中的终点，可能受到死亡率的唯一评估可能有限。环境毒素化学2021; 00：1-11。 （c）2021 Setac

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