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首页> 外文期刊>Environmental toxicology and chemistry >In Vivo Transformation of a Novel Polyfluoroether Surfactant
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In Vivo Transformation of a Novel Polyfluoroether Surfactant

机译：在新型多氟醚表面活性剂的体内转化中

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Per- and polyfluoroalkyl substances are a class of fluorochemicals that can degrade into perfluoroalkyl acids, which are well known to be persistent in the environment. It is thus important that novel fluorinated surfactants be designed to degrade into small, nonbioaccumulative products. We report the biotransformation and elimination kinetics of one such novel polyfluorinated surfactant, di(polyfluoroether thioether(S)-oate) sulfonate (diFESOS), and its metabolites. Biotransformation was investigated in vitro using S9 liver fractions and in vivo in Sprague-Dawley rats. Rats dosed by oral gavage with diFESOS were found to have relatively fast elimination kinetics, with half-lives on the order of hours, compared with legacy fluorinated surfactants such as the disubstituted polyfluoroalkyl phosphates that have half-lives on the order of days. To interrogate degradation of the polyfluorinated chain, rats were then dosed with a polyfluoroether thioether alcohol (a suspected product of carboxylate cleavage of diFESOS) either orally or intravenously, and the novel metabolite 2H-3:2 polyfluoroether sulfonic acid (2H-3:2 PFESA) was identified. Perfluoropropionic acid was detected in rat urine and is likely a terminal product. The blood of orally dosed rats contained higher levels of metabolites than the blood of intravenously dosed rats, suggesting the importance of metabolism in the gut and liver. Elimination kinetics of all the novel metabolites were faster than their fully fluorinated counterparts. Environ Toxicol Chem 2021;00:1-9. (c) 2021 SETAC
机译：每种和多氟烷基物质是一类含氟化合物，可以降解到全氟烷基酸中，这是众所周知的环境中持久性。因此，重要的是，新型氟化表面活性剂设计成降低成小的非基础产品。我们报告了一种这样的新型多氟化表面活性剂DI（聚氟醚硫醚醚醚）磺酸盐（Difesos）及其代谢物的生物转化和消除动力学。使用S9肝级分和在Sprague-Dawley大鼠体内体外研究生物转化。发现口腔饲养剂的大鼠具有糊涂体具有相对较快的消除动力学，而在数小时的半衰期，与遗留氟化表面活性剂如二取代的多氟烷基磷酸盐相比，含有半衰期。为了询问多氟链的降解，然后口服或静脉内或静脉内或静脉内用多氟醚硫醚醇（Difesos的羧酸盐裂解的可疑产物），以及新的代谢物2H-3：2多氟醚磺酸（2H-3：2鉴定了PFESA）。在大鼠尿液中检测到全氟丙酸，很可能是末端产物。口服大鼠的血液含有更高水平的代谢物，而不是静脉内剂量大鼠的血液，表明代谢在肠道和肝脏中的重要性。消除所有新型代谢物的动力学比其完全氟化的对应物更快。环境毒素化学2021; 00：1-9。 （c）2021 Setac

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