Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes

Palanisamy Krishnan; Jagan Sundaram; Sharmila Salam; Nirmala Subramaniam; Ashok Mari; Gopalakrishnan Balaraman; Devaki Thiruvengadam

首页> 外文期刊>Environmental toxicology >Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes

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Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes

机译：Citral通过调节抗氧化剂和异骨代谢酶来抑制N-硝基乙酰胺诱导的肝细胞癌

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Hepatocellular carcinoma (HCC) ranks the sixth position among various cancers worldwide. Recent research shows that natural and dietary compounds possess many therapeutic effects. Citral is a monoterpene aldehyde that contains geranial and neral. The present study was considered to study the role of citral against N-nitrosodiethylamine (NDEA)-induced HCC via modulation of antioxidants and xenobiotic-metabolizing enzymes in vivo. NDEA-alone-administered group Ⅱ animals profoundly showed increased tumor incidence, reactive oxygen species, liver marker enzyme levels, serum bilirubin levels, tumor markers of carcinoembryonic antigen, a-fetoprotein, proliferative markers of argyrophilic nucleolar organizing regions, proliferating cell nuclear antigen (PCNA) expressions, phase Ⅰ xenobiotic-metabolic enzymes and simultaneously decreased antioxidants, and phase Ⅱ enzymes levels. Citral (100 mg/kg b.w.) treatment significantly reverted the levels in group Ⅲ cancer-bearing animals when compared to group Ⅱ cancer-bearing animals. In group Ⅳ animals, citral-alone administration did not produce any adverse effect during the experimental condition. Based on the results, citral significantly inhibits the hepatocellular carcinogenesis through restoring the antioxidants and phase Ⅱ xenobiotic-enzyme levels; thereby, it strongly proves as an antiproliferative agent against rat HCC.

机译：肝细胞癌（HCC）在全球各种癌症中排名第六位。最近的研究表明，天然和膳食化合物具有许多治疗效果。柠檬兰是一个单色醛，含有大颌骨和裸体。认为本研究旨在通过在体内调节抗氧化剂和异骨 - 代谢酶的调节来研究CICRATH对N-硝基乙酰胺（NDEA）诱导的HCC的作用。 NDEA-施用的Ⅱ类动物深入显示肿瘤发病率，反应性氧物种，肝脏标记酶水平，血清胆红素水平，癌胚抗原的肿瘤标志物，胎儿蛋白，艾滋病毒核仁组织区的增殖标记，增殖细胞核抗原（ PCNA）表达，Ⅰ阶段异黄代谢酶，同时降低抗氧化剂和Ⅱ相酶水平。与Ⅱ组致癌动物相比，Citral（100mg / kg B.W.）治疗显着恢复了Ⅲ组癌症动物的水平。在Ⅳ组动物中，养分药物在实验条件下没有产生任何不利影响。基于结果，柠檬兰通过恢复抗氧化剂和Ⅱ期异黄素水平而显着抑制肝细胞癌;因此，它强烈证明是对大鼠HCC的抗增殖剂。

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来源
《Environmental toxicology》 |2020年第10期|971-981|共11页
作者
Palanisamy Krishnan; Jagan Sundaram; Sharmila Salam; Nirmala Subramaniam; Ashok Mari; Gopalakrishnan Balaraman; Devaki Thiruvengadam;
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作者单位

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

Molecular Oncology Lab Department of Biochemistry University of Madras Chennai India;

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正文语种 eng
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关键词
citral; N-nitrosodiethylamine; ROS; serum tumor marker enzymes; xenobiotic enzymes;

机译：柠;N-硝基二乙胺;ROS;血清肿瘤标志物酶;Xenobiotic酶;

Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes

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