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首页> 外文期刊>Environmental toxicology >Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA-PAA nano-encapsulation on PANC-1 pancreatic cancer cell line
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Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA-PAA nano-encapsulation on PANC-1 pancreatic cancer cell line

机译：Pang-1胰腺癌细胞系PLGA-PAA纳米封装的羟基吡咯溶胶和姜黄素的增强抗癌效力

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摘要

Many chemotherapeutic regimens have been investigated for advanced unresectable and metastatic pancreatic cancer (PC), but with only minimal improvement in survival and prognosis. Here, we investigated anti-cancer function of free and nano-encapsulated hydroxytyrosol (Hyd) and curcumin (Cur), and its combinations (Hyd-Cur) on PANC-1 cell line. The poly lactide-co-glycolide-co-polyacrylic acid (PLGA-co-PAA) nano-encapsulated Hyd and Cur were synthesized, and MTT assay was performed to evaluate cytotoxic effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur. Effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur were evaluated on viability, migration, morphological alterations, colony formation, and apopto-sis on PANC-1 cells. We observed that free and nano-encapsulated Hyd, Cur, and Hyd-Cur significantly increased apoptosis rates as well as significantly decreased viability, migration, and colony formation in PANC-1 cells. According to our results, Hyd-Cur combination and nano-encapsulation therapy exerts more profound apopto-tic and anti-proliferative effects on PANC-1 cells than free Hyd or Hyd monotherapy.
机译：已经研究了许多化学治疗方案，用于高级不可切除和转移性胰腺癌（PC），但只有最小的存活和预后的改善。在此，我们研究了Panc-1细胞系的自由和纳米封装的羟基吡咯（HYD）和姜黄素（CUR）的抗癌功能及其组合（HYP-Cur）。合成聚丙交酯 - 共乙酰基 - 共聚丙烯酸（PLGA-CO-PAA）纳米包封的HYD和CUR，并进行MTT测定以评估自由和纳米包裹的HYD，CUR和HYD-的细胞毒性效应cur。在PanC-1细胞上对可生存度，迁移，形态改变，菌落形成和Apophto-sis评估了游离和纳米封装的HYP，Cur和HYP-Cur的影响。我们观察到，自由和纳米包封的HYD，CU和HYP-Cur显着增加了凋亡率，并且在Panc-1细胞中显着降低了活力，迁移和菌落形成。根据我们的结果，HYD-CUR组合和纳米包封治疗对Panc-1细胞的抗增殖作用更加深吸，而不是自由水或水疗法。

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  • 来源
    《Environmental toxicology》 |2021年第6期|1043-1051|共9页
  • 作者

    Mahdieh Farhoudi Sefidan Jadid; Behrouz Shademan; Reza Chavoshi; Nasrin Seyyedsani; Elnaz Aghaei; Elham Taheri; Pouya Goleij; Saba Hajazimian; Vahidreza Karamad; Javad Behroozi; Mehrdad Nasrollahzadeh Sabet; Alireza Isazadeh; Behzad Baradaran;

  • 作者单位

    Department of Genetics Tabriz Branch Islamic Azad University Tabriz Iran;

    Department of Medical Biology Faculty of Medicine Ege University Izmir Turkey;

    Department of Genetics Tabriz Branch Islamic Azad University Tabriz Iran;

    Department of Genetics Tabriz Branch Islamic Azad University Tabriz Iran;

    Department of Genetics Arsanjan Branch Islamic Azad University Arsanjan Iran;

    Department of Pharmaceutical Biotechnology Tabriz University of Medical Sciences Tabriz Iran;

    Department of Genetics Faculty of Biology Sana Institute of Higher Education Sari Iran;

    Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran;

    Department of Medical Biology Faculty of Medicine Ege University Izmir Turkey;

    Department of Genetics and Biotechnology School of Medicine AJA University of Medical Sciences Tehran Iran;

    Department of Genetics and Biotechnology School of Medicine AJA University of Medical Sciences Tehran Iran;

    Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran;

    Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    apoptosis; curcumin; hydroxytyrosol; pancreatic cancer; PLGA-PAA copolymer;

    机译：细胞凋亡;姜黄素;羟基溶胶;胰腺癌;PLGA-PAA共聚物;

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