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首页> 外文期刊>Epidemiology and Infection >Population-based study of human papillomavirus infection and cervical neoplasia in Athens, Greece
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Population-based study of human papillomavirus infection and cervical neoplasia in Athens, Greece

机译：基于人群的希腊雅典人乳头瘤病毒感染和宫颈肿瘤的研究

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The aim of our study is to describe the prevalence of the different HPV types in women with preneoplastic lesions of the cervix in Greece. Cervical scrapes from 841 women were obtained for both cytological evaluation and analysis for the presence of HPV DNA. PCR was performed on specimens from these 841 women. The Pap test results were normal or showed benign cellular changes in 45·8% of the women, atypical squamous cells of undeterminated significance (ASCUS) in 23·2%, low-grade squamous intra-epithelial lesion (LSIL) in 27·9% and high-grade squamous intra-epithelial lesion (HSIL) in 3·1 %. HPV DNA was demonstrated in 23·6% of cytologically normal women. We detected HPV in 60% of the total samples. Of these, HPV-16 was the most common HPV DNA detected. Interestingly, HPV-58 was inversely correlated with positive cytological findings. A clear pattern of decreasing prevalence of HPV with age was also observed. Our results indicate that HPV infections, especially those with HPV-16, represent a significant public health concern in Greece.
机译：我们研究的目的是描述在希腊患有宫颈癌前病变的女性中不同HPV类型的患病率。从841名妇女的宫颈碎片中获得了HPV DNA的细胞学评估和分析。对这841名妇女的标本进行了PCR。 Pap检测结果正常或有良性细胞改变的女性为45·8％，未定意义的非典型鳞状上皮细胞（ASCUS）为23·2％，低度鳞状上皮内病变（LSIL）为27·9。 ％和高度鳞状上皮内病变（HSIL）占3·1％。在23·6％的细胞学正常女性中证实了HPV DNA。我们在总样本中检测了60％的HPV。其中，HPV-16是检测到的最常见的HPV DNA。有趣的是，HPV-58与阳性细胞学检查结果呈负相关。还观察到明显的HPV流行率随年龄下降的模式。我们的结果表明，HPV感染，尤其是HPV-16感染，在希腊代表了重大的公共卫生问题。

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