...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Pediatrics >Persistence of protection of hepatitis B vaccine and response to booster immunization in 2- to 12-year-old children
【24h】

Persistence of protection of hepatitis B vaccine and response to booster immunization in 2- to 12-year-old children

机译：持续保护2至12岁儿童的乙肝疫苗和加强免疫的反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neonatal vaccination against hepatitis B virus (HBV) infection was launched in 1998 in Turkey. The aim was to evaluate the persistence of seroprotection after HBV vaccination in order to determine the necessity of a single booster dose in 2- to 12-year-old children. This study was conducted retrospectively using hospital records of the children aged 2–12 years old who attended the pediatric outpatient clinics of Diskapi Training and Research Hospital, Ankara, Turkey between January 2010 and June 2011. Children who had received three doses of HBV vaccination in their infancy were included. A total of 530 children enrolled into the study, and 352 (66.4 %) of them had protective antibody to hepatitis surface antigens (anti-HBs) titer greater than 10 mIU/ml. The proportions of children with low, intermediate, and high anti-HB titers are different for those under 3 years of age. The majority were in the intermediate category. Those aged 4–10 years and 11 or older represented two-thirds of the children with high titers (p = 0.000). None of the children had chronic HBV infection. Unprotected children responded well after receiving the booster dose. The mean anti-HB concentration after the booster dose was more than 200 times higher than the mean antibody concentration before (p 0.001). Conclusion: Our data suggest that HBV vaccination may confer long-term immunity. Use of routine booster doses of vaccine at these ages does not appear necessary to maintain long-term protection in successfully vaccinated immunocompetent children in the region.
机译：1998年在土耳其启动了针对乙型肝炎病毒（HBV）感染的新生儿疫苗。目的是评估HBV疫苗接种后血清保护的持久性，以确定2至12岁儿童中单次加强剂量的必要性。这项研究是对2010年1月至2011年6月间在土耳其安卡拉Diskapi培训与研究医院的儿科门诊就诊的2至12岁儿童的医院记录进行的回顾性研究。在2007年接受了三剂HBV疫苗接种的儿童他们的婴儿期也包括在内。共有530名儿童参加了该研究，其中352名（66.4％）的肝炎表面抗原（抗HBs）保护性抗体滴度大于10 mIU / ml。低，中和高抗-HB滴度的儿童比例在3岁以下有所不同。大多数属于中级类别。滴度高的儿童中，年龄在4-10岁且11岁或以上的儿童占三分之二（p = 0.000）。没有一个孩子患有慢性HBV感染。未加保护的儿童在接受加强剂量后反应良好。加强剂量后的平均抗HB浓度比之前的平均抗体浓度高200倍以上（p <0.001）。结论：我们的数据表明，HBV疫苗接种可以赋予长期免疫力。对于在该地区成功接种疫苗的有免疫能力的儿童，在这些年龄使用常规加强剂量的疫苗似乎并不需要维持长期保护。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号