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Japanese Wild Mice: A Rich Resource for New Disease Models

机译：日本野生小鼠：新疾病模型的丰富资源

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摘要

Breeding of fancy mice has been a tradition in Japan. Recent progress in animal science has shed a new light on Japanese wild-derived mice as tools for discovery of new disease models because these mice, Mus musculus molossinus, are genetically far remote from the majority of available laboratory mice. After decades of effort, five inbred strains of mice have been established from pairs of wild mice trapped in Tohoku, northeastern Japan, namely K0R1/Stm, K0R5/Stm, KOR7/Stm, AlZ/Stm, and MAE/Stm. They carried numerous mutations, leading to a variety of diseases. During the inbreeding of K0R1, the first spontaneous mutation was found in the Apoe (apolipoprotein E) gene, and the mutant was later designated as spontaneous hyperlipidemic (SHL). Thereafter, a number of other mutations were discovered among wild-derived inbred strains, including atopic dermatitis, microphthalmia, dominant white spots, sebaceous gland abnormalities, and audible song-like vocalization. Furthermore, to examine the possible effects of the genetic background for these mutant genes, sets of congenic strains were generated, in which the mutant gene was introduced into at least 3 different strains of laboratory mice, including BALB/c and C57BL/6. These congenic strains have now been established as novel disease models. These wildderived inbred strains serve as a treasure trove for novel disease models. Most of them have been deposited in the Riken BioResource Center (BRC), and some are also available from commercial breeders.
机译：在日本，饲养花式小鼠一直是一种传统。动物科学的最新进展为发现日本野生动物作为发现新疾病模型的工具提供了新的思路，因为这些小鼠在遗传上与大多数现有的实验室小鼠相距甚远。经过数十年的努力，从困在日本东北东北地区的成对野生小鼠中建立了五只自交系小鼠，即K0R1 / Stm，K0R5 / Stm，KOR7 / Stm，AlZ / Stm和MAE / Stm。它们携带许多突变，导致多种疾病。在K0R1的近交过程中，在Apoe（载脂蛋白E）基因中发现了第一个自发突变，后来将该突变体称为自发性高脂血症（SHL）。此后，在野生近交系中发现了许多其他突变，包括特应性皮炎，小眼症，显性白斑，皮脂腺异常和可听歌样发声。此外，为了检查遗传背景对这些突变基因的可能影响，生成了一组同系菌株，其中将突变基因引入了至少3种不同的实验室小鼠品系，包括BALB / c和C57BL / 6。这些同系菌株现已建立为新型疾病模型。这些野生自交系作为新型疾病模型的宝库。它们中的大多数已存放在Riken生物资源中心（BRC）中，有些也可以从商业育种者处获得。

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  • 来源
    《Experimental Animals》 |2012年第1期|p.25-33|共9页
  • 作者

    Yoshibumi MATSUSHIMA;

  • 作者单位

    Saitama Cancer Center, Research Institute for Clinical Oncology, 818 Ina, Kitaadachi, Saitama 362-0806, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hyperlipidemia; KOR1; M. m. molossinus; mutant strains; wild mice;

    机译：高脂血症KOR1;M.米。莫洛西努斯突变株野生老鼠;

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