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Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats

机译：橙油对大鼠恩诺沙星口服吸收的影响

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摘要

This study was conducted to evaluate the oral absorption of enrofloxacin (ENFX) in rats when administered with orange oil or its main component, limonene. Compared with the group administered ENFX alone, the ENFX + limonene group did not show any significant difference in the absorption of ENFX, whereas the extent and rate of absorption of ENFX were significantly decreased in the ENFX + orange oil group (C_(max),-43%; T_(max), 129%). In addition, t_(1/2λz) and MRT of ENFX were prolonged by the concomitant administration of orange oil. The AUCs of ENFX were not affected in the ENFX + orange oil group. These results suggest that decreased oral absorption could reduce the efficacy of ENFX therapy in animals.
机译：进行这项研究的目的是评估在与橙油或其主要成分柠檬烯合用时大鼠口服恩诺沙星（ENFX）的吸收情况。与单独使用ENFX的组相比，ENFX +柠檬烯组对ENFX的吸收没有显示任何显着差异，而在ENFX +橙油组中，ENFX的吸收程度和吸收率显着降低（C_（max）， -43％； T_（max），129％）。此外，同时服用橙油可延长ENFX的t_（1 /2λz）和MRT。 ENFX +橙油组不影响ENFX​​的AUC。这些结果表明，口服吸收减少可能会降低ENFX治疗动物的功效。

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  • 来源
    《Experimental Animals》 |2012年第1期|p.71-75|共5页
  • 作者

    Jong-Hwan LIM; Myoung-Seok KIM; Youn-Hwan HWANG; In-Bae SONG; Tae-Won KIM; Hyo-In YUN;

  • 作者单位

    B&C Biopharm, Suwon, Gyeonggi 443-759;

    Jeollanamdo Development Institute for TraditionalKorean Medicine, Jangheung, Jeollanam 529-851;

    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea;

    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea;

    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea;

    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    enrofloxacin; limonene; orange oil;

    机译：恩诺沙星柠檬烯橙油;

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