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Genetic Materials at the Gene Engineering Division, RIKEN BioResource Center

机译：理化学生物资源中心基因工程部遗传材料

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摘要

Genetic materials are one of the most important and fundamental research resources for studying biological phenomena. Scientific need for genetic materials has been increasing and will never cease. Ever since it was established as RIKEN DNA Bank in 1987, the Gene Engineering Division of RIKEN BioResource Center (BRC) has been engaged in the collection, maintenance, storage, propagation, quality control, and distribution of genetic resources developed mainly by the Japanese research community. When RIKEN BRC was inaugurated in 2001, RIKEN DNA Bank was incorporated as one of its six Divisions, the Gene Engineering Division. The Gene Engineering Division was selected as a core facility for the genetic resources of mammalian and microbe origin by the National BioResource Project (NBRP) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan in 2002. With support from the scientific community, the Division now holds over 3 million clones of genetic materials for distribution. The genetic resources include cloned DNAs, gene libraries (e.g., cDNA and genomic DNA cloned into phage, cosmid, BAC, phosmid, and YAC), vectors, hosts, recombinant viruses, and ordered library sets derived from animal cells, including human and mouse cells, microorganisms, and viruses. Recently genetic materials produced by a few MEXT national research projects were transferred to the Gene Engineering Division for further dissemination. The Gene Engineering Division performs rigorous quality control of reproducibility, restriction enzyme mapping and nucleotide sequences of clones to ensure the reproducibility of in vivo and in vitro experiments. Users can easily access our genetic materials through the internet and obtain the DNA resources for a minimal fee. Not only the materials, but also information of features and technology related to the materials are provided via the web site of RIKEN BRC. Training courses are also given to transfer the technology for handling viral vectors. RIKEN BRC supports scientists around the world in the use of valuable genetic materials.
机译：遗传物质是研究生物现象的最重要，最基础的研究资源之一。对遗传物质的科学需求一直在增加，而且永远不会停止。自1987年成立RIKEN DNA库以来，RIKEN生物资源中心（BRC）的基因工程部一直致力于日本研究开发的遗传资源的收集，维护，储存，繁殖，质量控制和分配社区。当RIKEN BRC于2001年成立时，RIKEN DNA Bank成为其六个部门之一，即基因工程部门。 2002年，日本教育，文化，体育，科学和技术部（MEXT）的国家生物资源计划（NBRP）将基因工程部选为哺乳动物和微生物起源遗传资源的核心设施。在支持下该部门目前拥有来自科学界的300万个遗传材料克隆，用于分发。遗传资源包括克隆的DNA，基因文库（例如，克隆到噬菌体，粘粒，BAC，膦和YAC中的cDNA和基因组DNA），载体，宿主，重组病毒以及源自动物细胞（包括人和小鼠）的有序文库集细胞，微生物和病毒。最近，一些MEXT国家研究项目生产的遗传材料被转移到基因工程部门进行进一步传播。基因工程部对重现性，限制酶作图和克隆的核苷酸序列进行严格的质量控制，以确保体内和体外实验的重现性。用户可以通过互联网轻松访问我们的遗传材料，并以最低的费用获得DNA资源。通过RIKEN BRC的网站，不仅提供了材料，而且还提供了与这些材料有关的特征和技术的信息。还提供了培训课程，以转移用于处理病毒载体的技术。 RIKEN BRC支持世界各地的科学家使用有价值的遗传材料。

著录项

  • 来源
    《Experimental Animals》 |2010年第2期|p.115-124|共10页
  • 作者

    Kazunari K. YOKOYAMA; Takehide MURATA; Jianzhi PAN; Koji NAKADE; Shotaro KISHIKAWA; Hideyo UGAI; Makoto KIMURA; Yukari KUJIME; Megumi HIROSE; Satoko MASUZAKI; Takahito YAMASAKI; Chitose KURIHARA; Masato OKUBO; Yuri NAKANO; Yuka KUSA; Akiko YOSHIKAWA; Kumiko INABE; Kazuko UENO; Yuichi OBATA;

  • 作者单位

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan Center of Excellence for Environmental Medicine, Graduate Institute of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan Institute of Veterinary and Animal Husbandry, Zhejiang Academy of Agriculture Sciences, 198 Shiqiao Road, Hangzhou, Zhejiang 310021, China;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan Imamoto Cellular Dynamics Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

    Gene Engineering Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    genetic material; genome; recombinant virus; quality control;

    机译：基因材料基因组重组病毒质量控制;

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