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Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Lepr~(fa) Rats

机译：自发性糖尿病大鼠Torii-Lepr〜（fa）的血压评估

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摘要

The Spontaneously Diabetic Torii-Lepr~(fa) (SDT-falfa) rat, a new model of obese type 2 diabetes, shows obesity, hyperglycemia, and hyperlipidemia from 6 weeks of age. Diabetic complications such as nephropathy and cataract are observed with aging; however, blood pressure change with age has not previously been examined. In this study, blood pressure was periodically measured and the change was investigated. Blood pressure in male SDT-falfa rats was elevated at 8,16, and 24 weeks of age, whereas the heart rate was not changed. In addition to hyperglycemia, hyperlipidemia, and proteinuria, hyperleptinemia and increased urine angiotensinogen were observed in SDT-falfa rats. Blood pressure and heart rate in the male original SDT (SDT-+/+) rat did not significantly change. In conclusion, the SDT-falfa rat is a promising model, showing significant hypertension with diabetes mellitus.
机译：自发性糖尿病性Torii-Lepr〜（fa）（SDT-falfa）大鼠是肥胖的2型糖尿病的新模型，从6周龄开始出现肥胖，高血糖和高脂血症。随着年龄的增长，观察到糖尿病并发症，例如肾病和白内障。但是，血压没有随着年龄的增长而变化。在这项研究中，定期测量血压并研究其变化。雄性SDT-苜蓿大鼠的血压在8,16和24周龄时升高，而心率没有变化。除了高血糖，高脂血症和蛋白尿外，在SDT-苜蓿大鼠中还观察到高瘦素血症和尿血管紧张素原增加。雄性原始SDT（SDT-+ / +）大鼠的血压和心率没有明显变化。总之，SDT-苜蓿大鼠是一种有前途的模型，显示出患有糖尿病的显着高血压。

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  • 来源
    《Experimental Animals》 |2010年第4期|P.525-529|共5页
  • 作者

    Yukihito ISHII; Mimi MAKI; Hiromi YAMAMOTO; Tomohiko SASASE; Makoto KAKUTANI; Takeshi OHTA;

  • 作者单位

    Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;

    Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;

    Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;

    Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;

    Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;

    Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    blood pressure; diabetes; SDT-falfa rat;

    机译：血压;糖尿病;SDT鼠草;

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