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首页> 外文期刊>Experimental Animals >Augmented Induction of Antigen-Specific Cytotoxic T Cell Responses against Canine Hepatitis by Co-Immunization with pVAX1-CpG-Loop and Adjuvants in BALB/c Mice
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Augmented Induction of Antigen-Specific Cytotoxic T Cell Responses against Canine Hepatitis by Co-Immunization with pVAX1-CpG-Loop and Adjuvants in BALB/c Mice

机译：通过与pVAX1-CpG-Loop和佐剂共免疫BALB / c小鼠，增强了对犬肝炎的抗原特异性细胞毒性T细胞反应的诱导

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摘要

The objective of this study was to obtain better antigen specific cytotoxic T cell responses in vivo. We examined the augmented induction of antigen-specific cytotoxic T cell responses to co-administration of oligonucleotides (CpG-ODN), dimethyl dioctadecyl ammonium bromide (DDA), and Lipofectamine? 2000 with a DNA vaccine (pVAX1-CpG-Loop) and boosting with pVAX1-CpG-Loop in BALB/c mice. The results show that Loop protein-specific T cell proliferation, cytotoxic T cell activity, and the production of CD8+ T cells and IFN-γ were enhanced after co-immunization of mice with adjuvants and pVAX1-CpG-Loop. We demonstrated that significant T cell-mediated immune responses were induced in the mice with the help of DDA, CpG-ODN and Lipofectamine? 2000.
机译：这项研究的目的是在体内获得更好的抗原特异性细胞毒性T细胞反应。我们研究了寡核苷酸（CpG-ODN），二甲基二十八烷基溴化铵（DDA）和Lipofectamine？共同给药对抗原特异性细胞毒性T细胞应答的增强诱导作用。 2000年用DNA疫苗（pVAX1-CpG-Loop）接种，并用pVAX1-CpG-Loop在BALB / c小鼠中加强免疫。结果表明，用佐剂和pVAX1-CpG-Loop共同免疫小鼠后，Loop蛋白特异性T细胞增殖，细胞毒性T细胞活性以及CD8 + T细胞和IFN-γ的产生得以增强。我们证明了借助DDA，CpG-ODN和Lipofectamine？可以在小鼠中诱导出明显的T细胞介导的免疫反应。 2000。

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  • 来源
    《Experimental Animals》 |2010年第5期|p.579-588|共10页
  • 作者

    FuYing LIU; rnJingLi SHANG; rnShuXia SONG; rnLong ZHENG; rnKaiXia ZHANG; Hong Yu YOU; rnHuanLing ZHANG; rnJunXia WANG;

  • 作者单位

    Hebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

    rnHebei Key Lab of Laboratory Animal, Department of Molecular Biology,Hebei Medical University, Shijiazhuang 050017, PR China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    adjuvants; BALB/c mice; cytotoxic T cell responses; plasmid pVAX1-CpG-loop;

    机译：佐剂BALB / c小鼠;细胞毒性T细胞反应;质粒pVAX1-CpG-loop;

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