...
首页> 外文期刊>Experimental Animals >The Effects of Interleukin-6 and Cytokine-Induced Neutrophil Chemoattractant-1 on α_2-Macroglobulin Production In Rats
【24h】

The Effects of Interleukin-6 and Cytokine-Induced Neutrophil Chemoattractant-1 on α_2-Macroglobulin Production In Rats

机译:白细胞介素6和细胞因子诱导的中性粒细胞趋化因子-1对大鼠α_2-巨球蛋白产生的影响

获取原文
获取原文并翻译 | 示例
           

摘要

We investigated the effects of interleukin-6 (IL-6) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) on α_2-macroglobulin (α2M) production in rats. IL-6-rich and CINC-1-rich fractions were separated from serum obtained from rats 12 h after injection with turpentine oil using gel-chromatography. Sexual dimorphism was observed in the peak levels of α2M after injection of IL-6-, CINC-1-, or a mixture of IL-6-and-CINC-1-rich fractions. No significant differences in α2M levels were observed in males after injection with IL-6- or CINC-1-rich fractions and those injected with normal serum obtained from healthy rats (control). In contrast, serum levels of α2M, 6 to 120 h after injection of a mixture of IL-6-and CINC-1-rich fractions were significantly higher than in control rats. These results suggest that IL-6 and CINC-1 contribute to α2M production in rats only when IL-6 and CINC-1 act synergistically.
机译:我们调查了白细胞介素6(IL-6)和细胞因子诱导的中性粒细胞趋化因子-1(CINC-1)对大鼠α_2-巨球蛋白(α2M)产生的影响。使用凝胶色谱法从注射松节油后12小时的大鼠血清中分离出富含IL-6和富含CINC-1的组分。注射IL-6,CINC-1-或富含IL-6和CINC-1的混合物后,在α2M的峰值水平中观察到性二态性。注射富含IL-6或CINC-1的级分的雄性和注射自健康大鼠的正常血清(对照组)的雄性相比,α2M水平无显着差异。相反,注射富含IL-6和CINC-1的混合液后6至120 h,血清α2M水平明显高于对照组。这些结果表明,仅当IL-6和CINC-1协同作用时,IL-6和CINC-1才有助于大鼠产生α2M。

著录项

  • 来源
    《Experimental Animals》 |2010年第5期|p.589-594|共6页
  • 作者单位

    Seminar on Environment Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201;

    rnLaboratory of Immunology, School of Life and Environmental Science,Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201;

    rnLaboratory of Immunology, School of Life and Environmental Science,Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201;

    rnLaboratory of Immunology, School of Life and Environmental Science,Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201;

    rnLaboratory of Immunology, School of Life and Environmental Science,Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201;

    rnLaboratory of Physiology, Department of Food and Nutrition, Kamakura Women's University, 6-7-3 Ofuna, Kamakura, Kanagawa 247-8512, Japan;

    rnLaboratory of Immunology, School of Life and Environmental Science,Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    α2M; CINC-1; cytokine; IL-6; rat;

    机译:α2M;5-1;细胞因子IL-6;鼠;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号