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首页> 外文期刊>Experimental Animals >Effects of the Ih Blockers CsCI and ZD7288 on Inherited Epilepsy in Mongolian Gerbils
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Effects of the Ih Blockers CsCI and ZD7288 on Inherited Epilepsy in Mongolian Gerbils

机译：Ih阻断剂CsCI和ZD7288对蒙古沙鼠的遗传性癫痫的影响

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摘要

The h current (Ih) is an inwardly mixed cationic conductance activated by membrane hyperpolarization. We previously demonstrated that the Ih blockers CsCI and ZD7288 can significantly increase the threshold of electrically induced paroxysmal discharge in the rabbit hippocampus. In the present study, we examined the effects of these Ih blockers on inherited epilepsy in Mongolian gerbils. Seizure-sensitive Mongolian gerbils (n=29) underwent a series of seizure induction tests (including gentle handling for 1-2 min and being dropped from a height of 50 cm) before, during and after oral administration of 10 mM CsCI or 0.1 mM ZD 7288. Their behavioral responses were classified into 3 grades corresponding to no seizure (score: 0), partial seizure (score: 1), and generalized seizure (score: 2). In the CsCI experiments (n=10), the average scores were 1.09 ± 0.10 before administration, 0.82 ± 0.10 during administration, and 0.96 ± 0.10 after administration. CsCI significantly increased the ratio of grade 0 behavioral responses (P < 0.01, compared with the value before administration), and decreased the ratio of grade 1 responses (P < 0.01). In the ZD7288 experiments (n-19), the average scores were 0.99 ± 0.07 before administration, 0.52 ± 0.06 (P < 0.01) during administration, and 0.76 ± 0.07 (P < 0.05) after administration. ZD7288 significantly increased the ratio of grade 0 behavioral responses (P < 0.01), and decreased the ratio of grade 1 responses (P < 0.05) and grade 2 responses (P < 0.01). We conclude that both CsCI and ZD7288 have an anti-epileptic effect on inherited epilepsy in Mongolian gerbils.
机译：h电流（Ih）是由膜超极化激活的内向混合阳离子电导。我们先前证明，Ih阻断剂CsCI和ZD7288可以显着增加兔海马体中电诱发的阵发性放电的阈值。在本研究中，我们研究了这些Ih阻滞剂对蒙古沙鼠遗传性癫痫的影响。对癫痫敏感的蒙古沙鼠（n = 29）在口服10 mM CsCI或0.1 mM之前，期间和之后进行了一系列癫痫发作诱导测试（包括轻柔地处理1-2分钟并从50 cm的高度掉落） ZD7288。他们的行为反应分为3级，分别是无惊厥（分数：0），部分惊厥（分数：1）和全身性惊厥（分数：2）。在CsCI实验中（n = 10），平均得分在服药前为1.09±0.10，在服药过程中为0.82±0.10，在服药后为0.96±0.10。 CsCI显着提高了0级行为反应的比例（与给药前的值相比，P <0.01），并降低了1级行为反应的比例（P <0.01）。在ZD7288实验（n-19）中，平均得分为服药前0.99±0.07，服药期间0.52±0.06（P <0.01）和服药后0.76±0.07（P <0.05）。 ZD7288显着提高了0级行为反应的比例（P <0.01），并降低了1级行为反应的比例（P <0.05）和2级反应的比例（P <0.01）。我们得出结论，CsCI和ZD7288都对蒙古沙鼠的遗传性癫痫有抗癫痫作用。

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