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首页> 外文期刊>Experimental Animals >Effecs Of Cypermethrin On Some Biochemical Changes In Rats: The Protective Role Of Propolis
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Effecs Of Cypermethrin On Some Biochemical Changes In Rats: The Protective Role Of Propolis

机译：氯氰菊酯对大鼠某些生化变化的影响：蜂胶的保护作用

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Twenty eight female Wistar rats weighing 150-200 g were used in this study and these animals were divided into 4 groups, each comprising 7 rats. The first group served as the control group, and groups 2, 3, and 4 were administered a single dose of 250 mg/kg.bw propolis, a single dose of 125 mg/kg.bw (1/2LD_(50)) cypermethrin, and a single dose of 125 mg/kg.bw cypermethrin followed by a single dose of 250 mg/kg.bw propolis 30 min later, per os using a catheter, respectively. Twenty-four hours after propolis administration, blood and tissue (liver, kidney, and brain) samples were collected. Serum glucose, triglyceride, uric acid, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities/levels, plasma and tissue malondialdehyde (MDA) levels, and erythrocyte and tissue superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were determined. Compared to group 1, significant increases in plasma and tissue MDA levels and kidney GSH-Px activity, and significant decreases in erythrocyte SOD and CAT, liver SOD and GSH-Px, kidney SOD and brain SOD, CAT and GSH-Px activities were determined in group 3. Compared to group 1, a significant increase in glucose and a significant decrease in triglyceride levels were determined in group 3. Values pertaining to group 4 were demonstrated to be closer to those of group 1.
机译：在这项研究中使用了28只体重为150-200 g的雌性Wistar大鼠，将这些动物分为4组，每组包括7只大鼠。第一组为对照组，第2、3和4组分别服用250 mg / kg.bw蜂胶，125 mg / kg.bw（1 / 2LD_（50））氯氰菊酯，然后分别在30分钟后使用导管通过单剂量125 mg / kg.bw的氯氰菊酯和250 mg / kg.bw蜂胶的单剂量。服用蜂胶后二十四小时，收集血液和组织（肝脏，肾脏和大脑）样本。血清葡萄糖，甘油三酸酯，尿酸，胆固醇，天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）的活性/水平，血浆和组织丙二醛（MDA）的水平以及红细胞和组织的超氧化物歧化酶（SOD），确定过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）的活性。与第1组相比，测定了血浆和组织MDA水平的显着增加以及肾脏GSH-Px活性，而红细胞SOD和CAT，肝SOD和GSH-Px，肾脏SOD和脑SOD，CAT和GSH-Px活性显着降低在第3组中，与第1组相比，在第3组中确定了葡萄糖的显着增加和甘油三酸酯水平的显着下降。事实证明，与第4组相关的值更接近于第1组。

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