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Analysis of hybrid breakdown occurring in sib mating between two different mouse subspecies

机译：两个不同小鼠亚种同胞交配中发生的杂种优势分析

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Depression of reproduction or embryonic death can be observed in intersubspecific hybrids after 2nd generation of mating in mice. This 'hybrid breakdown' may be due to genetic incompatibilities caused by nucleotide polymorphisms found in genes of both subspecies. Such genetic incompatibilities are thought to affect those reproduction or embryogenesis in hybrids. Here we carried out sib (sister - brother)-mating experiments using offspring from two different subspecies, which were C57BL/6J (M. m. domesticus) and MSM/Ms (M m. molossinus). The mating was continued to the 5th generation. We found that their litter size continuously declined as the generation number increased in several different families. There were significant differences in their median litter size per delivery between the 1st and the 5th generation. We also found that number of ovulated eggs decreased significantly in the 5th generation compared to the 1st generation individuals. Ovaries of poor morphology were specifically found in 5th generation. It was previously reported that hybrid breakdown / sterility was caused by abnormalities in spermatogenesis. Here we suggest that reduction of reproductive ability in females is also a factor of hybrid breakdown.
机译：在小鼠第二代交配后，在亚种间杂种中可以观察到繁殖抑制或胚胎死亡。这种“杂交破坏”可能是由于两个亚种的基因中存在的核苷酸多态性引起的遗传不相容性。认为这种遗传不相容性会影响杂种的繁殖或胚胎发生。在这里，我们使用来自两个不同亚种的后代进行同胞（姐妹-兄弟）交配实验，这两个亚种分别是C57BL / 6J（家蝇）和MSM / Ms（鼠尾草）。交配一直持续到第五代。我们发现，随着几个不同家庭中世代数量的增加，它们的窝产仔数不断下降。第1代和第5代之间的平均产仔数存在显着差异。我们还发现，与第一代个体相比，第五代的排卵卵数量显着减少。形态较差的卵巢在第5代中特别发现。以前有报道说杂种的分解/不育是由精子发生异常引起的。在这里，我们建议女性生殖能力的下降也是杂交失败的一个因素。

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