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Changes of the gut environment during cigarette smoke exposure in Wistar Kyoto rats

机译：Wistar Kyoto大鼠接触香烟烟雾期间肠道环境的变化

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摘要

Many noxious materials contained in tobacco are distributed systemically via the lungs after inhaling tobacco smoke. In this study, to investigate whether the gut environment is affected by cigarette smoke or not, we examined changes in population of micro-flora, concentrations of certain organic acids and the pH of cecal contents in Wistar Kyoto (WKY/Izm) rats following 4 weeks exposure to cigarette smoke. We also measured body weight as an index of systemic effect, and we measured the balance of oxidant/antioxidant in plasma with reactive oxygen metabolites (ROMs) and Oxy-Adsorbent Test (Oxy). Cigarette smoke exposure caused a significant decrease in both the population of Bifldobacterium and concentration of total organic acid. The decrease in total organic acid levels was founded to be related not only to a decrease in body weight gain but also to an imbalance in Oxy levels with regard to ROM levels in plasma. In smoking group the pH was significantly elevated compared to non-smoking group. In conclusion, cigarette smoke negatively changed the gut environment and those changes may contribute to systemic disorders induced by cigarette smoke.
机译：吸入烟草烟雾后，烟草中包含的许多有害物质通过肺系统分布。在这项研究中，为调查肠道环境是否受到香烟烟雾的影响，我们研究了4周后Wistar Kyoto（WKY / Izm）大鼠的微生物区系，某些有机酸浓度和盲肠内含物pH的变化。接触香烟烟雾数周。我们还测量了体重，将其作为全身作用的指标，并测量了血浆中氧化剂/抗氧化剂与活性氧代谢物（ROM）和氧吸附试验（Oxy）的平衡。接触香烟烟雾导致双歧杆菌种群和总有机酸浓度显着下降。总有机酸水平的降低不仅与体重增加的降低有关，而且与血浆中ROM水平方面的Oxy水平不平衡有关。与不吸烟组相比，吸烟组的pH显着升高。总之，香烟烟雾对肠道环境产生了负面影响，这些变化可能导致香烟烟雾引起的系统性疾病。

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