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Highly sensitive model for GVHD using seven immunodeficient NOG mice

机译：使用七只免疫缺陷性NOG小鼠的GVHD高度敏感模型

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摘要

Graft versus host disease (GVHD) is a serious complication in allogeneic bone marrow transplantation caused by severe infiltration of donor lymphocytes into various organs of the recipient. Several animal models for GVHD are available known in immunodeficient mice, such as scid and NOD-scid, with human peripheral blood mononuclear cell (PBMC) transplantation. However these models have problems, including the need for lethal total body irradiation of the mice and a large number of PBMCs to induce GVHD, as well as instability in the timing of onset of GVHD symptoms. NOD/Shi- scid γc~(null) (NOG) mice developed in our institute have a major advantage in high engraftment rate of human cells compared with other immunodeficient mice due to their higher immunodeficiency. We report here a new model for highly sensitive xeno-GVHD using NOG mice. These mice showed early onset of GVHD symptoms and sufficient induction of GVHD with small numbers of human PBMCs when compared with NOD-.sc/J and BALB/cA-RAG2~(null) γc~(null) mice. In addition, total body irradiation is not necessary with this model. These results suggest that our model using the NOG mouse is useful to investigate xeno-GVHD.
机译：移植物抗宿主病（GVHD）是同种异体骨髓移植中的严重并发症，其原因是供体淋巴细胞严重渗入受体的各个器官。 GVHD的几种动物模型可在免疫缺陷小鼠中获得，例如scid和NOD-scid，以及人外周血单核细胞（PBMC）移植。但是，这些模型存在问题，包括需要对小鼠进行致命的全身照射和大量PBMC诱导GVHD，以及GVHD症状发作时机的不稳定性。与其他免疫缺陷小鼠相比，本研究所开发的NOD / Shiscidγc〜（null）（NOG）小鼠与其他免疫缺陷小鼠相比，在人类细胞高植入率方面具有主要优势。我们在这里报告了一种使用NOG小鼠的高敏感性异种GVHD的新模型。与NOD-.sc/J和BALB / cA-RAG2〜（null）γc〜（null）小鼠相比，这些小鼠表现出GVHD症状的早期发作和少量人PBMC对GVHD的充分诱导。另外，该型号不需要全身照射。这些结果表明，使用NOG小鼠的模型对于研究xeno-GVHD是有用的。

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