Mapping the host locus controlling malaria parasite exclusion in mice

Tamio Ohno; Masako Kuga; Tomohiro Soda; Takahiro Mamkawa; Kouki Shimada

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Mapping the host locus controlling malaria parasite exclusion in mice

机译：绘制控制小鼠疟疾寄生虫排斥的宿主基因图

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Linkage analysis by crossing susceptible NC/Jic and resistant 129Xl/SvJ mouse strains revealed a strong host resistance locus, designated Pymr ( Plasmodium yoelii malaria resistance locus) on Chr.9. Malaria parasites proliferated less in mice of the congenic strain possessing the Pymr region of 129Xl/SvJ on the NC/Jic background (NC.129X1- Pymr). Nonetheless, this strain exhibited delayed exclusion of malaria parasites compared with the 129X1/SvJ strain. Here, we performed linkage analysis between the NC. 129X1- Pymr and 129Xl/SvJ strains to identify the genetic locus which determined parasite exclusion.

机译：通过交叉易感的NC / Jic和抗性129X1 / SvJ小鼠品系进行的连锁分析显示，Chr.9上有一个强大的宿主抗性基因座，称为Pymr（约氏疟原虫疟疾抗性基因座）。在NC / Jic背景下具有129X1 / SvJ Pymr区的同基因株小鼠中，疟原虫的增殖较少。但是，与129X1 / SvJ菌株相比，该菌株显示出疟疾寄生虫的延迟排斥。在这里，我们进行了NC之间的链接分析。 129X1- Pymr和129X1 / SvJ菌株可鉴定决定寄生虫排斥的遗传基因座。

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来源
《Experimental Animals》 |2008年第3supa期|p.36|共1页
作者
Tamio Ohno; Masako Kuga; Tomohiro Soda; Takahiro Mamkawa; Kouki Shimada;
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作者单位

Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagova University;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类动物学;
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3. Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human Chromosome 5q31-q33 [J] . Maria Hernandez-Valladares, Pascal Rihet, Onesmo K. ole-MoiYoi, Immunogenetics . 2004,第2期

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机译：内源性胰岛素样肽和蚊子宿主中疟原虫感染的控制。
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机译：由疟疾寄生虫产生的植物激素水杨酸控制宿主免疫和脑疟疾结果。

Mapping the host locus controlling malaria parasite exclusion in mice

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