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Transgenic rabbit models for the study of cardiovascular disease

机译:研究心血管疾病的转基因兔模型

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摘要

Metabolic syndrome is a cluster of metabolic disorder including visceral obesity, hypertension, dyslipidemia and insulin resistance. Although this disease is not directly life-threatening, numerous clinical studies have shown that metabolic syndrome patients have increased incidence and mortality of cardiovascular disease such as myocardial infarction and stroke. To elucidate the pathological mechanisms of this disease and also develop a new therapeutic method for treatment, it is essential to use animal models. Until now, many animal models (most of which are mice and rats) have been used to study each aspect of metabolic syndrome, however, few of them can recapitulate final events, cardiovascular diseases. In this regard, our laboratory has been using rabbits for the study of hyperlipidemia and atherosclerosis. Compared to the rodents, rabbits have several advantages in terms of their metabolic features and cardiovascular systems.
机译:代谢综合征是一组代谢紊乱,包括内脏肥胖,高血压,血脂异常和胰岛素抵抗。尽管这种疾病并不直接威胁生命,但许多临床研究表明,代谢综合征患者增加了诸如心肌梗塞和中风之类的心血管疾病的发病率和死亡率。为了阐明该疾病的病理机制并开发新的治疗方法,必须使用动物模型。迄今为止,已经使用了许多动物模型(其中大多数是小鼠和大鼠)来研究代谢综合症的各个方面,但是,很少有动物模型可以概括最终事件,心血管疾病。在这方面,我们的实验室一直在使用兔子研究高脂血症和动脉粥样硬化。与啮齿动物相比,兔子在其代谢特征和心血管系统方面具有许多优势。

著录项

  • 来源
    《Experimental Animals》 |2008年第3supa期|p.17|共1页
  • 作者

    Jianglin Fan;

  • 作者单位

    Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物学;
  • 关键词

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