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首页> 外文期刊>Experimental Animals >Light-Induced Phase-Shifting of the Peripheral Circadian Oscillator in the Hearts of Food-Deprived Mice
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Light-Induced Phase-Shifting of the Peripheral Circadian Oscillator in the Hearts of Food-Deprived Mice

机译：缺食小鼠心脏中周围昼夜节律振荡器的光诱导相移。

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摘要

In the present study, we investigated the effect of fasting on photoentrainment of the peripheral circadian oscillator in the mammalian heart. Northern blotting showed that a single light pulse applied at an appropriate time in constant darkness, caused obvious phase-shifting in the circadian expression rhythm of the mammalian clock gene Period2 (mPer2) even in the hearts of food-deprived mice. Fasting did not significantly affect either the phase or the light-induced phase-shifts of the mPer2 rhythm. Although several studies of temporal feeding restriction have indicated that feeding is the dominant timing cue for mammalian peripheral oscillators, our findings suggest that feeding is not essential for mammals to induce phase resetting of the circadian oscillator in the heart.
机译：在本研究中，我们调查了禁食对哺乳动物心脏中外周昼夜节律振荡器的光携带的影响。 Northern印迹表明，在恒定的黑暗中在适当的时间施加单个光脉冲，即使在食物缺乏的小鼠的心脏中，哺乳动物时钟基因Period2（mPer2）的昼夜表达节律也引起明显的相移。空腹没有显着影响mPer2节奏的相位或光诱导的相移。尽管对暂时性进食限制的多项研究表明，进食是哺乳动物外周振荡器的主要计时线索，但我们的发现表明，进食对于哺乳动物在心脏中诱导昼夜节律振荡器的相位重置不是必不可少的。

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