...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Experimental Animals >Newly Established Low Seizure Susceptible and Seizure-Prone Inbred Strains of Mongolian Gerbil
【24h】

Newly Established Low Seizure Susceptible and Seizure-Prone Inbred Strains of Mongolian Gerbil

机译：蒙古沙鼠新近建立的低癫痫易感性和癫痫发作近交系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two inbred strains of the Mongolian gerbil with different phenotypes in seizure behaviour and coat color were newly established. LSAG/Nu has low seizure susceptibility and albino phenotypes, whereas SPBG/Nu has seizure-prone and black coat color phenotypes. LSAG was compared with SPBG as to seizure incidence and grade. Mean ages at seizure onset of LSAG and SPBG were 6 and 3 months, respectively. Seizure incidences in over 9 months old LSAG and SPBG gerbils were 37.3% (66/177) and 95.2% (118/124), respectively. LSAG has a significantly lower incidence (p<0.001) and grade (p<0.001) of seizures than SPBG. Only a few seizing LSAG gerbils exhibited myoclonus to tonic-clonic seizure progression. These results suggest that LSAG has some mechanisms which delay the onset of seizures and prevent them from becoming serious. Both strains of gerbils can be expected to be useful animal models for the study of human idiopathic generalized epilepsy.
机译：新建立了两个自发表现出不同的癫痫行为和外壳颜色的蒙古沙鼠近交系。 LSAG / Nu的癫痫易感性和白化病表型低，而SPBG / Nu的癫痫易发性和黑毛色表型。将LSAG和SPBG的癫痫发作发生率和等级进行比较。 LSAG和SPBG发作的平均年龄分别为6个月和3个月。超过9个月大的LSAG和SPBG沙鼠的癫痫发作发生率分别为37.3％（66/177）和95.2％（118/124）。 LSAG的癫痫发作率（p <0.001）和等级（p <0.001）明显低于SPBG。只有少数癫痫发作的沙鼠表现出肌阵挛到强直阵挛性癫痫发作。这些结果表明，LSAG具有一些机制，可以延迟癫痫发作的发生并防止其变得严重。两种沙鼠菌株都有望成为研究人类特发性全身性癫痫的有用动物模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号