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首页> 外文期刊>Experimental Animals >Ratio of Leptin to Adiponectin as an Obesity Index of Cynomolgus Monkeys (Macaca fascicularis)
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Ratio of Leptin to Adiponectin as an Obesity Index of Cynomolgus Monkeys (Macaca fascicularis)

机译：瘦素与脂联素的比率作为食蟹猴的肥胖指数。

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摘要

Obesity is responsible for inducing various metabolic diseases. Laboratory-bred cynomolgus monkeys exhibit spontaneous onset of obesity. However, to date, no blood chemistry index to identify the state of obesity in cynomolgus monkeys has been determined. In the present study, to determine such an index, we measured the serum levels of two adipocyte-derived hormones, leptin and adiponectin, and evaluated the relationship between these hormones and other serum energy metabolic factors (i.e. insulin, total protein, glucose, total cholesterol and triglyceride) as well as the percentage of body fat (%Fat) in mature cynomolgus monkeys. Both in females and males, leptin was positively correlated with insulin and %Fat, and adiponectin was negatively correlated with insulin and %Fat. In female cynomolgus monkeys, leptin, adiponectin, and glucose were selected as the most important determinants for %Fat in multiple regression analysis, and in male cynomolgus monkeys, leptin was selected. The ratio of leptin to adiponectin (L/A ratio) was significantly elevated in the animals with %Fat over 40 (P<0.01). The results indicate that L/A ratio is a potential index for comprehensively identifying obesity in cynomolgus monkeys.
机译：肥胖是引起各种代谢疾病的原因。实验室饲养的食蟹猴表现出肥胖的自发发作。然而，迄今为止，尚未确定用于确定食蟹猴肥胖状态的血液化学指标。在本研究中，为了确定这样的指标，我们测量了两种脂肪细胞源激素，瘦素和脂联素的血清水平，并评估了这些激素与其他血清能量代谢因子（即胰岛素，总蛋白，葡萄糖，总胆固醇）之间的关系。胆固醇和甘油三酸酯）以及成熟食蟹猴体内脂肪的百分比（％脂肪）。在女性和男性中，瘦素与胰岛素和％脂肪呈正相关，而脂联素与胰岛素和％脂肪呈负相关。在雌性食蟹猴中，选择瘦素，脂联素和葡萄糖作为多元回归分析中％Fat的最重要决定因素，在雄性食蟹猴中，选择瘦素。在％脂肪超过40的动物中，瘦素与脂联素的比率（L / A比率）显着提高（P <0.01）。结果表明，L / A比是综合识别食蟹猴肥胖的潜在指标。

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