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首页> 外文期刊>Experimental Animals >Compairson of Age-Related Peripheral Nerve Changes in Mice Housed in Either Plastic Cages with Sawdust-Covered Solid Flooring or Wire-Mesh-Floor Cages
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Compairson of Age-Related Peripheral Nerve Changes in Mice Housed in Either Plastic Cages with Sawdust-Covered Solid Flooring or Wire-Mesh-Floor Cages

机译:装有木屑覆盖固体地板或金属丝网地板笼的塑料笼中小鼠年龄相关的外周神经变化的比较

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摘要

A comparative histologic survey was conducted on the dorsal root, sciatic, tibial and medial plantar nerves of 90-and 110-week-old B6C3F1 female mice reared in either solid-floor cages covered in sawdust or wire-mesh-floor cages. Age-related peripheral nerve lesions, characterized by axonal degeneration and remyelination, were present in all nerves surveyed, and were especially prominent in the sciatic and medial plantar nerves at 110 weeks of age but, there were no differences associated with the type of cage floor in clinical signs, grasping power to the fore-and hind-limbs, motor nerve conduction velocity of histopathologic findings at these ages.
机译:对90周和110周龄B6C3F1雌性小鼠的背根,坐骨神经,胫骨和内侧足底神经进行了比较组织学调查,这些小鼠饲养在木屑笼或金属丝网笼中。与年龄相关的周围神经病变以轴突变性和髓鞘再生为特征,在所有接受调查的神经中均存在,并且在110周龄时在坐骨神经和足底内侧神经中尤为突出,但与笼底类型无关在临床征象中,这些年龄段的前肢和后肢的抓地力,组织病理学发现的运动神经传导速度。

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