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Mapping of the Dilute-Opisthotonus (dop) Gene on Chromosome 8 of the Rat

机译:在大鼠的第8染色体上的稀释鱼腥藻(dop)基因的映射。

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摘要

The rat dilute-opisthotonus (dop) autosomal recessive gene, causing ataxia and coat color dilution, was mapped on chromosome 8 by PCR-amplified microsatellite markers. To facilitate the linkage analysis, an intersubspecific cross with a Japanese wild rat strain was used. The recombination frequencies were 12.8% between Apoc3 and dop, and 32.1% between dop and Mylc 1v. The following order of three genes is proposed; Apoc3-dop-Mylc 1v. This mutation appears to be homologous to dilute-lethal (d~l) of the mouse in terms of clinical symptoms, coat color effect and chromosomal location of the gene loci.
机译:将导致共济失调和毛色稀薄的大鼠稀性阿司匹林(dop)常染色体隐性基因通过PCR扩增的微卫星标记定位在第8号染色体上。为了促进连锁分析,使用了与日本野生大鼠品系的亚种间杂交。 Apoc3和dop之间的重组频率为12.8%,而dop和Mylc 1v之间的重组频率为32.1%。提出了以下三个基因的顺序: Apoc3-dop-Mylc 1v。就临床症状,外壳颜色效应和基因位点的染色体位置而言,该突变似乎与小鼠的稀致死性(d_1)同源。

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