Effects of Gonadotropin Administration on Follicular Growth and In Vitro Fertilization in Female Hypogonadal Mice

Kazuyoshi HASHIZUME; Hirotada TSUJII; Makoto ROKUTANDA

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Effects of Gonadotropin Administration on Follicular Growth and In Vitro Fertilization in Female Hypogonadal Mice

机译：促性腺激素对雌性性腺功能减退小鼠卵泡生长和体外受精的影响

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Folliculogenesis in female hypogonadal (hpg) mice was examined after treatment with exogenous gonadotropins. The female mutant mice were characterized by a deficiency of hypothalamic gonadotropin-releasing hormone (GnRH), leading to the absence of estrus and ovulation. Gonadotropin administration induced resumption of gonadal development and vaginal opening. The follicles that developed with gonadotropin treatment were very similar to those in normal littermates. The oocytes from hpg mice showed the capacity for fertilization and development to produce viable young after in vitro fertilization and embryo transplantation. Thus, the combination of the exogenous gonadotropin administration, in vitro fertilization and embryo transfer method appear to be helpful to breed mutant hpg mice efficiently.

机译：外源性促性腺激素治疗后，检查雌性性腺机能减退（hpg）小鼠的卵泡形成。雌性突变小鼠的特征是缺乏下丘脑的促性腺激素释放激素（GnRH），导致没有发情和排卵。促性腺激素的施用诱导性腺发育和阴道开放的恢复。促性腺激素处理后形成的卵泡与正常同窝仔卵非常相似。在体外受精和胚胎移植后，来自hpg小鼠的卵母细胞显示出受精和发育的能力，可以生产出能存活的幼仔。因此，外源促性腺激素给药，体外受精和胚胎移植方法的结合似乎有助于有效地培育突变型hpg小鼠。

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来源
《Experimental Animals》 |1995年第3期|p.241-244|共4页
作者
Kazuyoshi HASHIZUME; Hirotada TSUJII; Makoto ROKUTANDA;
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作者单位

Laboratory of Female Reproductive Endocrinology, National Institute of Animal Industry, P.O. Box 5, Tsukuba Norindanchi, Ibaraki 305, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类动物学;
关键词
hpg; follicular growth; IVf;

机译：hpg;卵泡生长;IVf;

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专利

1. Preventing severe ovarian hyperstimulation syndrome in an in vitro fertilization/embryo transfer program. Use of follicular aspiration after human chorionic gonadotropin administration. [J] . Vrtovec HM, Tomazevic T Journal of Reproductive Medicine: The Official Periodical of the American Academy of Reproductive Medicine, Association of Professors of Gynecology and Obstetrics, International Family Planning Research Association ... [et al.] . 1995,第1期

机译：在体外受精/胚胎移植程序中预防严重的卵巢过度刺激综合征。人绒毛膜促性腺激素给药后滤泡抽吸的使用。
2. Preventing severe ovarian hyperstimulation syndrome in an in vitro fertilization/embryo transfer program. Use of follicular aspiration after human chorionic gonadotropin administration. [J] . Vrtovec HM, Tomazevic T Journal of Reproductive Medicine: The Official Periodical of the American Academy of Reproductive Medicine, Association of Professors of Gynecology and Obstetrics, International Family Planning Research Association ... [et al.] . 1995,第1期

机译：在体外受精/胚胎移植程序中预防严重的卵巢过度刺激综合征。人绒毛膜促性腺激素给药后滤泡抽吸的使用。
3. Ovulation and follicular growth in gonadotropin-treated gilts followed by in vitro fertilization and development of their oocytes [J] . D. Bolamba, M.-A.Sirard Theriogenology . 2000,第7期

机译：促性腺激素处理后备母猪的排卵和卵泡生长，然后体外受精和卵母细胞发育
4. PORCINE EMBRYO PRODUCTION BY IN VITRO FERTILIZATION OF OOCYTES MATURED IN VITRO USING NCSU-37 SUPPLEMENTED WITH 10 PORCINE FOLLICULAR FLUID (PFF) [C] . I.F.Andrade, rnM.M.Leao, rnA.A.F.Baiao, Current Status and Innovation in Animal Reproductive Biotechnology and Stem Cells . 2008

机译：使用添加10％猪卵泡液（PFF）的NCSU-37体外体外培养卵母细胞体外生产猪胚
5. Study of Human Ovarian Follicular Fluid High Density Lipoprotein (HDL) and Embryo Quality During in vitro Fertilization (IVF) [D] . Kim, Keewan 2015

机译：体外施肥期间人卵巢卵泡液高密度脂蛋白（HDL）和胚胎质量研究（IVF）
6. Efficacy of luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist priming protocol in poor responders undergoing in vitro fertilization [O] . Hwajeong Lee, Hyun Joung Choi, Kwang Moon Yang, 2018

机译：黄体雌激素的施用和早期卵泡促性腺激素释放激素拮抗剂引发方案在体外受精的不良反应者中的疗效
7. Effects of Gonadotropin Administration on Follicular Growth and In Vitro Fertilization in Female Hypogonadal Mice. [O] . Kazuyoshi HASHIZUME, Hirotada TSUJII, Makoto ROKUTANDA 1995

机译：促性腺激素给药对女性低因素小鼠卵泡生长和体外施肥的影响。
8. Consequences of Gonadotropin Administration on Fertilization and Early Embryonic Development in the Domestic Cat and the In Vitro Fertilization of Feline Follicular Oocytes. [R] . Goodrowe, K. L. 1987

机译：促性腺激素给药对家猫受精和早期胚胎发育及猫卵泡卵母细胞体外受精的影响。

Effects of Gonadotropin Administration on Follicular Growth and In Vitro Fertilization in Female Hypogonadal Mice

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