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首页> 外文期刊>Experimental Brain Research >Non-invasive stimulation of the vibrissal pad improves recovery of whisking function after simultaneous lesion of the facial and infraorbital nerves in rats
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Non-invasive stimulation of the vibrissal pad improves recovery of whisking function after simultaneous lesion of the facial and infraorbital nerves in rats

机译：大鼠面部和眶下神经同时受损伤后，无创刺激震颤垫可改善其拂动功能的恢复

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摘要

We have recently shown that manual stimulation of target muscles promotes functional recovery after transection and surgical repair to pure motor nerves (facial: whisking and blink reflex; hypoglossal: tongue position). However, following facial nerve repair, manual stimulation is detrimental if sensory afferent input is eliminated by, e.g., infraorbital nerve extirpation. To further understand the interplay between sensory input and motor recovery, we performed simultaneous cut-and-suture lesions on both the facial and the infraorbital nerves and examined whether stimulation of the sensory afferents from the vibrissae by a forced use would improve motor recovery. The efficacy of 3 treatment paradigms was assessed: removal of the contralateral vibrissae to ensure a maximal use of the ipsilateral ones (vibrissal stimulation; Group 2), manual stimulation of the ipsilateral vibrissal muscles (Group 3), and vibrissal stimulation followed by manual stimulation (Group 4). Data were compared to controls which underwent surgery but did not receive any treatment (Group 1). Four months after surgery, all three treatments significantly improved the amplitude of vibrissal whisking to 30° versus 11° in the controls of Group 1. The three treatments also reduced the degree of polyneuronal innervation of target muscle fibers to 37% versus 58% in Group 1. These findings indicate that forced vibrissal use and manual stimulation, either alone or sequentially, reduce target muscle polyinnervation and improve recovery of whisking function when both the sensory and the motor components of the trigemino-facial system regenerate.
机译：我们最近发现，对目标肌肉进行手动刺激可促进横切和手术修复纯运动神经后的功能恢复（面部：拂动和眨眼反射；舌下反射：舌头位置）。但是，在面神经修复之后，如果通过例如眶下神经切除消除感觉传入输入，则手动刺激是有害的。为了进一步理解感觉输入和运动恢复之间的相互作用，我们在面部和眶下神经上同时进行了切开和缝合的损伤，并研究了通过强制使用刺激触须刺激感觉传入是否会改善运动恢复。评估了3种治疗方式的功效：去除对侧触毛以确保最大程度地使用同侧触诊（振动刺激；第2组），手动刺激同侧触诊肌肉（第3组）以及振动刺激后进行手动刺激（第4组）。将数据与接受手术但未接受任何治疗的对照组进行比较（第1组）。手术后四个月，所有三种治疗均将第1组对照组的颤动颤动幅度显着提高至30°，而对照组为11°。这三种治疗也将目标肌纤维的多神经支配程度降低至37％，而组中为58％ 1.这些发现表明，当三叉神经-面部系统的感觉和运动成分都再生时，单独或顺序使用强制振动按摩和手动刺激可以减少目标肌肉的多神经支配，并改善搅拌功能的恢复。

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  • 来源
    《Experimental Brain Research》 |2011年第1期|p.65-79|共15页
  • 作者

    H. Bendella; S. P. Pavlov; M. Grosheva; A. Irintchev; S. K. Angelova; D. Merkel; N. Sinis; K. Kaidoglou; E. Skouras; S. A. Dunlop; Doychin N. Angelov;

  • 作者单位

    Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany;

    Department of Anatomy, Histology, Embryology, Medical University of Varna, Varna, Bulgaria;

    Department of Oto-Rhino-Laryngology, University of Cologne, Cologne, Germany;

    Department of Otorhinolaryngology, Friedrich-Schiller University Jena, Jena, Germany;

    Department of Oto-Rhino-Laryngology, University of Cologne, Cologne, Germany;

    Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany;

    Plastic Surgery Clinic, Martin-Luther-Hospital, Berlin, Germany;

    Department of Histology and Embryology, Aristotle University of Thessaloniki, Thessaloniki, Greece;

    Department of Orthopedics and Traumatology, University of Cologne, Cologne, Germany;

    Department of Anatomy I, Anatomical Institute at the University;

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  • 正文语种 eng
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  • 关键词

    Facial nerve; Trigeminal nerve; Regeneration; Manual stimulation; Vibrissal function;

    机译：面神经;三叉神经;再生;手部刺激;纤颤功能;

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