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首页> 外文期刊>Experimental Brain Research >Analysis of synchrony demonstrates that the presence of “pain networks” prior to a noxious stimulus can enable the perception of pain in response to that stimulus
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Analysis of synchrony demonstrates that the presence of “pain networks” prior to a noxious stimulus can enable the perception of pain in response to that stimulus

机译：同步性分析表明，有害刺激之前存在“疼痛网络”可以使人们对刺激产生疼痛感

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Our previous study has shown that directed attention to a painful stimulus is associated with increased synchrony between electrocorticographic (ECoG) oscillations in pain-related cortical structures. We now test the hypothesis that the synchrony or functional connectivity of this pain network differs between events during which pain is or is not perceived (pain or non-pain events) in response to a noxious cutaneous laser stimulus. ECoG recordings were made through subdural electrodes implanted in a patient for the treatment of epilepsy. The patient was instructed that the stimulus could be painful or non-painful on any given presentation. Synchrony between ECoG signals at different sites was measured during the pre-stimulus interval, and the difference in the number of sites with significant pre-stimulus synchrony was compared between pain and non-pain events. Pre-stimulus synchrony was more common during pain versus non-pain events among electrodes overall, and in the subset of electrodes at which laser-evoked potentials (LEPs) were recorded. This difference between pain and non-pain events was also significant for the subset of electrodes over medial cortex, including anterior cingulate cortex (ACC), but not for subsets of electrodes over the superior and inferior convexity, including primary somatosensory (S1) and parasylvian cortex (PS), respectively. These results suggest that dynamic changes in the functional connectivity between ACC and other cortical regions enable the perception of pain in response to noxious stimuli.
机译：我们以前的研究表明，对疼痛刺激的直接关注与疼痛相关的皮质结构中的皮质电图（ECoG）振荡之间的同步性增强有关。现在，我们测试以下假设：该疼痛网络的同步性或功能连通性在响应有害的皮肤激光刺激而感觉到或未感觉到疼痛的事件之间（疼痛或非疼痛事件）不同。 ECoG记录是通过植入患者的硬脑膜下电极来治疗癫痫的。指示患者在任何给定的表现上刺激都可能是痛苦的或非痛苦的。在刺激前的间隔内测量不同部位的ECoG信号之间的同步，并比较疼痛和非疼痛事件之间具有明显的刺激前同步的部位数量的差异。总体而言，在疼痛之间的刺激前同步比在非电极事件中更普遍，在记录激光诱发电位（LEP）的电极子集中也是如此。疼痛和非疼痛事件之间的这种差异对于内侧皮层上的电极子集（包括前扣带回皮质（ACC））也很重要，但对于上，下凸度上的电极子集（包括主要的体感（S1）和旁侧静脉）而言，则不明显皮质（PS）。这些结果表明，ACC和其他皮质区域之间功能连接的动态变化使人们能够感知到对有害刺激的疼痛感。

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