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首页> 外文期刊>Experimental Brain Research >Vestibular inputs to propriospinal interneurons in the feline C1-C2 spinal cord projecting to the C5-C6 ventral horn
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Vestibular inputs to propriospinal interneurons in the feline C1-C2 spinal cord projecting to the C5-C6 ventral horn

机译：猫C1 -C2 脊髓中脊椎前神经元的前庭输入投射到C5 -C6 腹角

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The resting length of respiratory muscles must be altered during changes in posture in order to maintain stable ventilation. Prior studies showed that although the vestibular system contributes to these adjustments in respiratory muscle activity, the medullary respiratory groups receive little vestibular input. Additionally, previous transneuronal tracing studies demonstrated that propriospinal interneurons in the C1-C2 spinal cord send projections to the ipsilateral diaphragm motor pool. The present study tested the hypothesis that C1-C2 interneurons mediate vestibular influences on diaphragm activity. Recordings were made from 145 C1-C2 neurons that could be antidromically activated from the ipsilateral C5-C6 ventral horn, 60 of which had spontaneous activity, during stimulation of vestibular receptors using electric current pulses or whole-body rotations in vertical planes. The firing of 19 of 31 spontaneously active neurons was modulated by vertical vestibular stimulation; the response vector orientations of many of these cells were closer to the pitch plane than the roll plane, and their response gains remained relatively constant across stimulus frequencies. Virtually all spontaneously active neurons responded robustly to electrical vestibular stimulation, and their response latencies were typically shorter than those for diaphragm motoneurons. Nonetheless, respiratory muscle responses to vestibular stimulation were still present after inactivation of the C1-C2 cord using large injections of either muscimol or ibotenic acid. These data suggest that C1-C2 propriospinal interneurons contribute to regulating posturally related responses of the diaphragm, although additional pathways are also involved in generating this activity.
机译：为了保持稳定的通气，姿势改变时必须改变呼吸肌的静止长度。先前的研究表明，尽管前庭系统有助于呼吸肌活动的这些调节，但延髓性呼吸系统组很少接受前庭输入。此外，以前的跨神经元追踪研究表明，C1 -C2 脊髓中的脊椎脊髓中枢神经元将投影投射到同侧pool肌运动池。本研究验证了C1 -C2 中间神经元介导前庭对diaphragm肌活动的影响的假说。记录了145个C1 -C2 神经元的声音，这些神经元可以从同侧C5 -C6 腹角被抗刺激地激活，其中60个具有自发性，在刺激前庭时接收器使用电流脉冲或在垂直平面上进行全身旋转。 31个自发活跃神经元中有19个的发射是通过垂直前庭刺激来调节的；这些细胞中的许多细胞的响应矢量方向比侧倾平面更靠近音高平面，并且它们的响应增益在刺激频率上保持相对恒定。几乎所有自发活动的神经元均对前庭电刺激产生强烈反应，其反应潜伏期通常短于diaphragm肌运动神经元。但是，通过大量注射麝香酚或异丁酸将C1 -C2 脐带灭活后，呼吸肌对前庭刺激的反应仍然存在。这些数据表明，C1 -C2 脊椎椎间神经元有助于调节diaphragm肌的姿势相关反应，尽管其他途径也参与了这种活动的产生。

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