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Saccadic latency distributions in Parkinson’s disease and the effects of l-dopa

机译：帕金森氏病的潜伏潜伏期分布和左旋多巴的影响

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摘要

Parkinson’s disease (PD) is associated with a loss of central dopaminergic pathways in the brain leading to an abnormality of movement, including saccades. In PD, analysis of saccadic latency distributions, rather than mean latencies, can provide much more information about how the neural decision process that precedes movement is affected by disease or medication. Subject to the constraints of intersubject variation and reproducibility, latency distribution may represent an attractive potential biomarker of PD. Here we report two studies that provide information about these parameters, and demonstrate a novel effect of dopamine on saccadic latency, implying that it influences the neural decision process itself. We performed a detailed cross-sectional study of saccadic latency distributions during a simple step task in 22 medicated patients and 27 age-matched controls. This revealed high intersubject variability and an overlap of PD and control distributions. A second study was undertaken on a different population specifically to investigate the effects of dopamine on saccadic latency distributions in 15 PD patients. l-dopa was found to prolong latency, although the magnitude of the effect varied between subjects. The implications of these observations for the use of saccadic latency distributions as a potential biomarker of PD are discussed, as are the effects of l-dopa on neural decision making, where it is postulated to increase the criterion level of evidence required before the decision to move is made.
机译：帕金森氏病（PD）与大脑中多巴胺能中枢通路的丢失有关，从而导致包括扫视在内的运动异常。在PD中，对行潜伏期分布（而不是平均潜伏期）的分析可以提供有关疾病或药物如何影响运动之前的神经决策过程的更多信息。受受试者间变异和可重复性的约束，潜伏期分布可能代表PD的潜在潜在生物标志物。在这里，我们报告了两项研究，这些研究提供了有关这些参数的信息，并证明了多巴胺对行潜伏期的新颖影响，这暗示着它会影响神经决策过程本身。我们对22名含药患者和27名年龄匹配的对照组进行了简单的步骤，对行潜伏期分布进行了详细的横断面研究。这表明受试者间的高度可变性以及PD和控制分布的重叠。针对不同的人群进行了第二项研究，专门研究了多巴胺对15名PD患者的行潜伏期分布的影响。发现左旋多巴可延长潜伏期，尽管影响的程度因受试者而异。讨论了这些观察结果对使用Saccadic潜伏期分布作为PD的潜在生物标志物的意义，以及左旋多巴对神经决策的影响，在此基础上，它被认为可以增加决策之前所需的标准证据水平。移动了。

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