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Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory

机译：海马后区的选择性细胞毒性病变在社会认知记忆中产生轻度缺陷

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Although a number of studies have implicated the hippocampal formation in social recognition memory in the rat, a recent study in this laboratory has demonstrated that selective cytotoxic lesions, confined to the hippocampus proper (encompassing the four CA subfields and the dentate gyrus), are without effect on this behaviour. This finding suggests that the hippocampus proper does not subserve social recognition memory in the rat, but does not preclude the possibility that other areas of the hippocampal formation, such as the entorhinal cortex or subiculum, could support this form of learning. The present study addressed this issue by examining the effects of selective cytotoxic retrohippocampal (RHR) lesions (including both the entorhinal cortex and subiculum) on social recognition memory in the rat. RHR lesions produced a mild social recognition memory impairment, although lesioned animals still displayed a reduction in investigation time between the first and second exposure to the juvenile. This result is consistent with other studies which have implicated the retrohippocampal or parahippocampal area in olfactory recognition memory processes. It also suggests, however, that other areas, outwith the retrohippocampal region, are also likely to play an important role in social recognition memory.
机译：尽管许多研究表明大鼠的海马区形成与社会认知记忆有关，但该实验室的一项最新研究表明，仅限于海马体固有的选择性细胞毒性病变（包括四个CA子域和齿状回）没有。对这种行为的影响。这一发现表明，海马体不能为大鼠提供社会认可的记忆，但并不排除海马体其他区域（例如内嗅皮层或下丘脑）可以支持这种学习方式的可能性。本研究通过检查选择性细胞毒性海马后（RHR）病变（包括内嗅皮层和下丘脑）对大鼠社交识别记忆的影响来解决此问题。 RHR病变产生了轻度的社会认知记忆障碍，尽管患病的动物在第一次和第二次接触幼体之间仍显示出减少的调查时间。该结果与其他研究牵连到海马后或海马旁区域的嗅觉识别记忆过程一致。然而，这也表明，除海马后区域以外的其他区域也可能在社会认知记忆中起重要作用。

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