The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro

Wanli Liu; Zhongyao Wu

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The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro

机译：环孢菌素A联合抗肿瘤药物对视网膜母细胞瘤的体外药物敏感性

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Purpose: To study cyelosporine A inhibition on the fresh retinoblastoma cells in vitro and increasing the drug sensitivity after combined with different antineoplastic drugs. Methods: To study the growth curve of cyelosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyelosporine A combined with seven antineoplastic drugs. Results: The average IC50 of cyelosporine A on the 27 retinoblastoma cells is 67.81 μg/ml and the average inhibitive rate of these samples is 26.1% when cyelosporine A is in the concentration of 2 μg/ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyelosporine A and the increasing average inhibitive rate is more than 5. Conclusion: Cyclosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. Moreover it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells.

机译：目的：研究环孢霉素A在体外对新鲜视网膜母细胞瘤细胞的抑制作用，并与不同的抗肿瘤药物联合使用以提高药物敏感性。方法：采用MTT法研究27例原代视网膜母细胞瘤细胞中Cylosporine A的生长曲线，并研究Cylosporine A联合7种抗肿瘤药对药物敏感性的变化。结果：cyporosporine A在浓度为2μg/ ml时，对27个视网膜母细胞瘤细胞的平均IC50为67.81μg/ ml，这些样品的平均抑制率为26.1％。七种抗肿瘤药联合环孢霉素A联合使用后，抑制率均有所提高，平均抑制率增加了5倍以上。结论：环孢霉素A可体外抑制视网膜母细胞瘤细胞，其抑制作用与剂量有关。此外，它可以增强多种抗肿瘤药对视网膜母细胞瘤细胞的抑制作用。

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《Eye Science》 |2005年第1期|p.62-6611|共6页
作者
Wanli Liu; Zhongyao Wu;
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作者单位

Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China;

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原文格式 PDF
正文语种 eng
中图分类 R7;
关键词
retinoblastoma; cyelosporine A; MTT assay;

机译：视网膜母细胞瘤;环孢素A;MTT测定;
入库时间 2022-08-18 00:50:50

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1. The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro [J] . Wanli Liu, Zhongyao Wu 眼科学报（英文版） . 2005,第001期

机译：环孢素A联合抗肿瘤药物对视网膜母细胞瘤的体外药敏
2. Combined Use of Anticancer Drugs and an Inhibitor of Multiple Drug Resistance-Associated Protein-1 Increases Sensitivity and Decreases Survival of Glioblastoma Multiforme Cells In Vitro [J] . Lilia Peigñan, Wallys Garrido, Rodrigo Segura, Neurochemical Research . 2011,第8期

机译：联合使用抗癌药和多种耐药相关蛋白1抑制剂可增加敏感性并降低胶质母细胞瘤多形细胞的存活率
3. Combined use of anticancer drugs and an inhibitor of multiple drug resistance-associated protein-1 increases sensitivity and decreases survival of glioblastoma multiforme cells in vitro. [J] . Peignan L, Garrido W, Segura R, Neurochemical research . 2011,第8期

机译：抗癌药和多种耐药相关蛋白1抑制剂的组合使用可提高多形性胶质母细胞瘤细胞的敏感性并降低其存活率。
4. Preliminary In-vitro Study of Surface Alterations of Subcutaneous Venous Access Ports Exposed to Antineoplastic Drugs and Whole Blood [C] . Maren K. Fossum, Emma Stroemberg, Javier Sanchez, TMS annual meeting exhibition . 2015

机译：暴露于抗肿瘤药和全血的皮下静脉通路的表面变化的体外初步研究
5. Formulation and delivery of drugs for macular edema and retinoblastoma; synthesis and in vitro characterization of doxorubicin loaded surface modified nanoparticles using PLGA-PEG-FOL polymer. [D] . Boddu, Sai Hanuman Sagar. 2010

机译：黄斑水肿和视网膜母细胞瘤药物的配制和投放； PLGA-PEG-FOL聚合物合成负载阿霉素的表面改性纳米粒子的合成和体外表征。
6. In vitro effect of amifostine on haematopoietic progenitors exposed to carboplatin and non-alkylating antineoplastic drugs: haematoprotection acts as a drug-specific progenitor rescue. [O] . L. Pierelli, G. Scambia, A. Fattorossi, 1998

机译：氨磷汀对暴露于卡铂和非烷基化抗肿瘤药的造血祖细胞的体外作用：血液保护作用可作为药物特异性祖细胞的拯救。
7. Formulation and in vitro evaluation of antineoplastic drug loaded nanoparticles as drug delivery system [O] . Dastagiri Reddy 2013

机译：抗肿瘤药物负载纳米粒子作为药物递送系统的制剂和体外评价

The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro

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