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Production of Hypoxia-induced Corneal Edema in Aged Eyes

机译：低氧引起的老年人眼角膜水肿的产生

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Purpose: Corneal thickness assessment is a common clinical procedure applied in corneal and contact lens care. This study aims to investigate the effect of age on hypoxia-induced corneal swelling. Methods: Eighteen male subjects were equally divided into the younger [(23.7 +- 0.8) years old] and older [(74.4 +- 2.5) years old] groups. Each subject wore a thick soft contact lens (uniform thickness of 0.3 mm) on the left cornea. With the contact lens in place, the baseline central corneal thickness was measured using a specially designed photo-pachometer. The lens was then patched behind the closed eyelids, producing an extremely hypoxic stress to the cornea. The change in central corneal thickness was monitored every 20 minutes with momentary disruptions to the hypoxic stress over the next 2 hours. The increase in thickness was taken as an index of corneal edema. The rate of change in corneal thickness, as derived from a non-linear mathematical model, was compared between groups. Results: The corneal thickness of both age groups increased significantly with time (P < 0.0001). The mean corneal swelling constant for the older subjects was 16.5 x 10~(-3) (S.E. M. = 2.65 X 10~(-3)) and the value for the younger subjects was 46.5 X 10~(-3) (S.E.M. = 3.25 x 10~(-3)). The difference was statistically significant (P < 0.0001). Conclusion: Aging cornea has a slower hypoxia-induced edema response compared with the younger group. Whether it is caused by a decreased corneal lactate production or an increased resistance to physical expansion deserves further investigation.
机译：目的：角膜厚度评估是应用于角膜和隐形眼镜护理的常见临床程序。这项研究旨在调查年龄对缺氧引起的角膜肿胀的影响。方法：将18名男性受试者平均分为较年轻的[（23.7 +-0.8）岁]和较老的[（74.4 +-2.5）岁]组。每位受试者的左角膜均戴有厚的软性隐形眼镜（厚度均匀，为0.3毫米）。戴好隐形眼镜后，使用专门设计的光速计测量基线中央角膜厚度。然后将晶状体贴在闭合的眼睑后面，对角膜产生极度缺氧的压力。每隔20分钟监测中央角膜厚度的变化，并在接下来的2小时内暂时破坏低氧应激。厚度的增加被认为是角膜水肿的指标。比较两组之间从非线性数学模型得出的角膜厚度变化率。结果：两个年龄组的角膜厚度均随时间显着增加（P <0.0001）。年龄较大的受试者的平均角膜肿胀常数为16.5 x 10〜（-3）（SEM = 2.65 X 10〜（-3）），年龄较小的受试者的平均值为46.5 X 10〜（-3）（SEM = 3.25） x 10〜（-3））。差异具有统计学意义（P <0.0001）。结论：与年轻组相比，角膜衰老对缺氧引起的水肿反应较慢。无论是由于角膜乳酸生成减少还是对物理膨胀的抵抗力增强，都值得进一步研究。

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