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首页> 外文期刊>Eye Science >Experimental Studies of Melanin Associated Antigen and Its Relationship with Sympathetic Ophthalmia and Vogt-Kayanagi-Harada Syndrome
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Experimental Studies of Melanin Associated Antigen and Its Relationship with Sympathetic Ophthalmia and Vogt-Kayanagi-Harada Syndrome

机译：黑色素相关抗原的实验研究及其与交感性眼病和Vogt-Koyanagi-Harada综合征的关系

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Purpose: To discuss the relationship of Bovine Melanin-Associated Antigen (BMAA) to Sympathetic Ophthalmia (SO) and Vogt-Kayanagi-Harada (VKH) syndrome. Methods: BMAA was isolated and purified from bovine iris and ciliary body and MTT method was used to measure the peripheral lymphocyte reactions of SO and VKH syndrome patients to BMAA. 15 cases of SO were included in the SO group with 11 males and 4 females.The average age was 37.5, ranging from 23 to 56 years; 15 patients with VKH syndrome were included in the VHK group with 7 males and 8 females. Their average age was 37.2 years, ranging from 24 to 69 years; 20 normal individuals without ocular and systemic autoimmune diseases were included in the control group. These included 9 males and 11 females, aging from 14 to 28 with an average of 23.8 years. Results: The OD values of each group were as follows: SO controls 0.327+-0.032; SO + BMAA 0.490+-0.758; SO+PHA 0.5310+-0.918; VKH controls 0.328+-0.503; VKH+BMAA 0.430+-0.530; VKH+PHA 0.328+-0.484; Normal controls 0.304+-0.267; Normal+BMAA 0.343+-0.326; Normal+PHA 0.477+-0.598. The average OD values of peripheral lymphocytes to BMAA stimulation in SO patients and normal controls were 0.490 and 0.343 respectively. The difference was statistically significant, P< 0.001; The average OD values of peripheral lymphocytes to BMAA stimulation in SO and VKH syndrome patients were 0.470 and 0.430 respectively. The difference was not statistically significant, P > 0.05. Conclusions: BMAA effectively stimulate the proliferative reaction of peripheral lymphocytes in SO patients and BMAA may act as an antigen and contribute in the pathological process of SO.No difference in proliferative reaction of peripheral lymphocytes was found between SO and VKH syndrome patients after BMAA stimulations and BMAA may be involved in the development of both SO and VKH syndrome.
机译：目的：探讨牛黑色素相关抗原（BMAA）与交感性眼病（SO）和沃格特-柳木原田（VKH）综合征的关系。方法：从牛虹膜和睫状体中分离纯化BMAA，MTT法检测SO和VKH综合征患者对BMAA的外周血淋巴细胞反应。 SO组中有15例SO患者，其中男11例，女4例。平均年龄37.5岁，年龄23至56岁。 VHK组包括15例VKH综合征患者，其中男7例，女8例。他们的平均年龄为37.2岁，从24岁到69岁不等。对照组中包括20名无眼和全身自身免疫性疾病的正常人。其中包括9名男性和11名女性，年龄从14岁到28岁，平均23.8岁。结果：各组的OD值如下：SO对照为0.327 + -0.032； SO对照为0.327 + -0.032。 SO + BMAA 0.490 + -0.758; SO + PHA 0.5310 + -0.918; VKH控制0.328 + -0.503； VKH + BMAA 0.430 + -0.530； VKH + PHA 0.328 + -0.484；正常对照0.304 + -0.267；正常+ BMAA 0.343 + -0.326；正常+ PHA 0.477 + -0.598。 SO患者和正常对照组外周血淋巴细胞对BMAA刺激的平均OD值分别为0.490和0.343。差异具有统计学意义，P <0.001； SO和VKH综合征患者外周血淋巴细胞对BMAA刺激的平均OD值分别为0.470和0.430。差异无统计学意义，P> 0.05。结论：BMAA有效刺激了SO患者外周血淋巴细胞的增殖反应，BMAA可能是SO的抗原并参与了SO的病理过程。BMAA刺激后，SO和VKH综合征患者外周血淋巴细胞的增殖反应没有差异。 BMAA可能参与SO和VKH综合征的发展。

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