Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

Shinya Dohgu; William A Banks

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Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

机译：脑周细胞增加了跨体外血脑屏障的，HIV-1无病毒的脂多糖增强的转胞作用：细胞因子介导的周细胞-内皮细胞串扰的证据

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Background Human immunodeficiency virus-1 (HIV-1) enters the brain by crossing the blood–brain barrier (BBB) as both free virus and within infected immune cells. Previous work showed that activation of the innate immune system with lipopolysaccharide (LPS) enhances free virus transport both in vivo and across monolayer monocultures of brain microvascular endothelial cells (BMECs) in vitro.

机译：背景技术人类免疫缺陷病毒1（HIV-1）作为自由病毒和在被感染的免疫细胞内穿过血脑屏障（BBB）进入大脑。先前的工作表明，用脂多糖（LPS）激活先天免疫系统可增强体内和跨脑微血管内皮细胞（BMEC）的单层单培养的自由病毒转运。

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《Fluids and Barriers of the CNS》 |2013年第1期|1-10|共10页
作者
Shinya Dohgu; William A Banks;
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正文语种 eng
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Blood–brain barrier HIV-1 Pericytes Brain endothelial cells Cytokines BMEC AIDS Neuroinflammation Neuroimmune Lipopolysaccharide;

机译：血脑屏障HIV-1周细胞脑内皮细胞细胞因子BMEC艾滋病神经炎症神经免疫脂多糖;

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1. Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk [J] . Shinya Dohgu, William A Banks Cerebrospinal Fluid Research . 2013,第1期

机译：脑周细胞增加了跨体外血脑屏障的，HIV-1无病毒的脂多糖增强的转吞作用：细胞因子介导的周细胞-内皮细胞串扰的证据
2. Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk [J] . Shinya Dohgu, William A Banks Fluids and Barriers of the CNS . 2013,第2期

机译：脑周细胞增加了跨体外血脑屏障的，HIV-1无病毒的脂多糖增强的转吞作用：细胞因子介导的周细胞-内皮细胞串扰的证据
3. Pericyte-endothelial cell interaction increases MMP-9 secretion at the blood-brain barrier in vitro. [J] . Zozulya A, Weidenfeller C, Galla HJ Brain research . 2008,第0期

机译：周细胞与内皮细胞的相互作用增加了体外血脑屏障的MMP-9分泌。
4. Developing a Fusion Protein Platform to Improve Blood-Brain Barrier Transcytosis of Immunoglobulin G Therapeutics [C] . Fabiana Zappala, Andrew Tsourkas Protein Engineering Summit. . 2018

机译：开发融合蛋白平台，以改善免疫球蛋白G治疗剂的血脑屏障转红菌病
5. Design of Nanoparticles That Cross the Blood-Brain Barrier by Receptor Mediated Transcytosis. [D] . Wiley, Devin Thomas. 2013

机译：通过受体介导的胞吞作用穿越血脑屏障的纳米颗粒的设计。
6. Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk [O] . Shinya Dohgu, William A Banks 2013

机译：脑周细胞增加了跨体外血脑屏障的HIV-1无病毒的脂多糖增强的转吞作用：细胞因子介导的周细胞-内皮细胞串扰的证据
7. Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk [O] . Shinya Dohgu, William A Banks 2013

机译：脑周细胞增加了跨体外血脑屏障的，HIV-1无病毒的脂多糖增强的转胞作用：细胞因子介导的周细胞-内皮细胞串扰的证据

Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood–brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

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