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首页> 外文期刊>Food Additives & Contaminants >Carry-over of veterinary drugs from medicated to non-medicated feeds in commercial feed manufacturing plants
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Carry-over of veterinary drugs from medicated to non-medicated feeds in commercial feed manufacturing plants

机译：在商业饲料生产工厂中将兽药从含药饲料转移到非含药饲料

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摘要

Different compound feeds have to be manufactured in the same production line. As a consequence, traces of the first produced feed may remain in the production and get mixed with the next feed batches. This "carry-over" is unavoidable, and so non-medicated feed can be contaminated with veterinary drugs like antibiotics added to the previous batch of medicated feed. To monitor the carry-over of antibiotics in the Netherlands, 21 feed mills were visited and 140 samples of flushing feeds were collected and analysed for containing residues of antibiotics. Results show that 87% of all samples contain concentrations of antibiotics in the range of 0.1-154 mg/kg. It is expected that these levels - which are in the same range as previously found for the nowadays banned antimicrobial growth promoters (AMGPs) - have an effect on the occurrence of microbial resistance. Analysis of a second set of samples collected at four different feed mills directly after the production of oxytetracycline-medicated feed demonstrated that the first part of a flushing feed has much higher contamination than the last part of the batch. Furthermore, it was demonstrated that the carry-over percentage shows no correlation with the carry-over determined by one of the standard GMP+ procedures. These observations, unavoidable carry-over, inhomogeneous batches of feed with antibiotics and difficulties to predict the carry-over levels, together with the awareness of the increasing problem of microbial resistance, motivated the NEVED1, association of Dutch Feed Producers, to announce that they will voluntarily stop the production of medicated feed in 2011. The alternatives for medicated feed are for example water or milk medication or the use of top-dressings at the farm. The consequences and possible new risks of carry-over at the farm are not completely clear yet.
机译：不同的复合饲料必须在同一条生产线上生产。结果，第一批生产的饲料的痕迹可能保留在生产中，并与下一批饲料混合。这种“残留”是不可避免的，因此未加药的饲料可能会被添加到前一批加药的饲料中的兽药如抗生素污染。为了监测荷兰的抗生素残留情况，访问了21家饲料厂，收集了140份冲洗饲料样品并分析了其中是否含有抗生素残留。结果表明，所有样品中有87％的抗生素浓度在0.1-154 mg / kg的范围内。预期这些水平-与当今被禁止的抗微生物生长促进剂（AMGP）所发现的水平相同-对微生物抗药性的发生有影响。生产土霉素药物后，立即在四个不同的饲料厂收集的第二组样品的分析表明，冲厕饲料的第一部分比批次的最后一部分具有更高的污染。此外，证明了残留率与标准GMP +程序之一测定的残留率无相关性。这些观察结果，不可避免的残留，含抗生素的饲料批次不均匀，难以预测残留水平以及对微生物耐药性日益增加的问题的认识，促使荷兰饲料生产商协会NEVED1宣布他们将在2011年自愿停止生产含药饲料。含药饲料的替代品包括水或奶类药物或在农场使用追肥。尚未完全弄清农场结转的后果和可能的新风险。

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  • 来源
    《Food Additives & Contaminants》 |2013年第6期|1100-1107|共8页
  • 作者

    A.A.M. Stolker; V. Manti; T. Zuidema; H. van Egmond; E.R. Deckers; R. Herbes; J. Hooglugt; E. Olde Heuvel; J. de Jong;

  • 作者单位

    RIKILT - Institute of Food Safety, Wageningen University and Research, Akkermaalsbos, Wageningen, the Netherlands;

    RIKILT - Institute of Food Safety, Wageningen University and Research, Akkermaalsbos, Wageningen, the Netherlands;

    RIKILT - Institute of Food Safety, Wageningen University and Research, Akkermaalsbos, Wageningen, the Netherlands;

    RIKILT - Institute of Food Safety, Wageningen University and Research, Akkermaalsbos, Wageningen, the Netherlands;

    Dutch Ministry of Economic Affairs, Prins Clauslaan, The Hague, the Netherlands;

    Dutch Food and Consumer Product Safety Authority,Catharijnesingel, Utrecht, the Netherlands;

    Dutch Food and Consumer Product Safety Authority,Catharijnesingel, Utrecht, the Netherlands;

    Dutch Food and Consumer Product Safety Authority,Catharijnesingel, Utrecht, the Netherlands;

    RIKILT - Institute of Food Safety, Wageningen University and Research, Akkermaalsbos, Wageningen, the Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    carry-over; analysis; oxytetracycline; antibiotics;

    机译：结转;分析;土霉素抗生素类;

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