Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray-drying processing

Loughrill Emma; Thompson Sharon; Owusu-Ware Samuel; Snowden Martin J.; Douroumis Dennis; Zand Nazanin

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Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray-drying processing

机译：通过喷雾干燥工艺控制释放微囊化二十二碳六烯酸（DHA）

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The omega-3-fatty acid, docosahexaenoic acid (DHA) 22:6 n-3, is an important food component for the visual and brain development of infants. In this study two approaches have been explored for the encapsulation of DHA in the pH dependant polymer hydroxyl-propyl-methyl-cellulose-acetate-succinate (HPMCAS). In the first approach Direct Spray Drying (DSD) was implemented for the microencapsulation of DHA/HPMCAS organic solutions, whilst in the second approach solid lipid nanoparticle (SLN) dispersions of DHA, were first produced by high-pressure homogenization, prior to being spray dried in HPMCAS aqueous solutions. The DSD approach resulted in significantly higher quantities of DHA being encapsulated, at 2.09 g/100 g compared to 0.60 g/100 g in the spray-dried SLNs. The DHA stability increased with the direct spray-drying approach. Release studies of DHA in the direct sprayed dried samples revealed a lag time for 2 h in acidic media followed by rapid release in phosphate buffer (pH 6.8).

机译：ω-3-脂肪酸二十二碳六烯酸（DHA）22：6 n-3是婴儿视觉和大脑发育的重要食物成分。在这项研究中，已经探索了两种方法将DHA封装在pH依赖性聚合物羟丙基甲基纤维素醋酸酯琥珀酸酯（HPMCAS）中。在第一种方法中，直接喷雾干燥（DSD）用于DHA / HPMCAS有机溶液的微囊化，而在第二种方法中，DHA的固体脂质纳米颗粒（SLN）分散体首先在喷雾之前通过高压均质化生产在HPMCAS水溶液中干燥。 DSD方法导致DHA的封装量大大增加，为2.09 g / 100 g，而喷雾干燥的SLN中的DHA封装为0.60 g / 100 g。直接喷雾干燥法增加了DHA的稳定性。 DHA在直接喷雾干燥样品中的释放研究表明，在酸性介质中滞后2小时，然后在磷酸盐缓冲液（pH 6.8）中快速释放。

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来源
《Food Chemistry》 |2019年第15期|368-375|共8页
作者
Loughrill Emma; Thompson Sharon; Owusu-Ware Samuel; Snowden Martin J.; Douroumis Dennis; Zand Nazanin;
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作者单位

Univ Greenwich, Fac Engn & Sci, Medway Campus, Chatham ME4 4TB, Kent, England;

Univ Greenwich, Fac Engn & Sci, Medway Campus, Chatham ME4 4TB, Kent, England;

Univ Greenwich, Fac Engn & Sci, Medway Campus, Chatham ME4 4TB, Kent, England;

Univ Greenwich, Fac Engn & Sci, Medway Campus, Chatham ME4 4TB, Kent, England;

Univ Greenwich, Fac Engn & Sci, Medway Campus, Chatham ME4 4TB, Kent, England;

Univ Greenwich, Fac Engn & Sci, Medway Campus, Chatham ME4 4TB, Kent, England;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
Nutraceuticals; Fish oil microencapsulation; Hydroxy propyl methyl cellulose acetate succinate (HPMCAS); Docosahexaenoic acid (DHA); Spray-drying; Solid lipid nanoparticle (SLN);

机译：营养食品;鱼油微囊化;羟丙基甲基纤维素乙酸琥珀酸酯（HPMCAS）;二十二碳六烯酸（DHA）;喷雾干燥;固体脂质纳米颗粒（SLN）;

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1. Toddler formula supplemented with docosahexaenoic acid (DHA) improves DHA status and respiratory health in a randomized, double-blind, controlled trial of US children less than 3 years of age. [J] . Minns LM, Kerling EH, Neely MR, Prostaglandins, Leukotrienes, and Essential Fatty Acids . 2010,第4a6期

机译：补充二十二碳六烯酸（DHA）的幼儿配方食品在一项针对美国3岁以下儿童的随机，双盲，对照试验中改善了DHA的状况和呼吸系统健康。
2. Effect of eicosapentaenoic acid/docosahexaenoic acid on coronary high-intensity plaques detected with non-contrast T1-weighted imaging (the AQUAMARINE EPA/DHA study): study protocol for a randomized controlled trial [J] . Kazuhiro Nakao, Teruo Noguchi, Yasuhide Asaumi, Trials . 2018,第1期

机译：二十碳五烯酸/二十二碳六烯酸对非造影剂T1加权成像检测到的冠状动脉高强度斑块的影响（AQUAMARINE EPA / DHA研究）：一项随机对照试验的研究方案
3. The differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on seizure frequency in patients with drug-resistant epilepsy - A randomized, double-blind, placebo-controlled trial [J] . Ibrahim Fatma A. S., Ghebremeskel Kebreab, Abdel-Rahman Manar E., Epilepsy & behavior: E&B . 2018,第期

机译：含二十甲苯乙烯酸（EPA）和二十二碳甲酸（DHA）对耐药性癫痫患者癫痫发作的差异影响 - 随机，双盲，安慰剂对照试验
4. Continuous Gradient Temperature Raman Spectroscopy of the Long Chain Polyunsaturated Fatty Acids Docosapentaenoic (DPA, 22:5n-6) and Docosahexaenoic (DHA; 22:6n-3) from-100 to 20℃ [C] . C. Leigh Broadhurst, Walter F. Schmidt, Moon S. Kim, Sensing for Agriculture and Food Quality and Safety VIII . 2016

机译：100至20℃的长链多不饱和脂肪酸二十碳五烯酸（DPA，22：5n-6）和二十二碳六烯酸（DHA; 22：6n-3）的连续梯度温度拉曼光谱
5. The differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on membrane lipid composition fluidity and function. [D] . Brown, Eric Raymond. 1994

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6. Comparing docosahexaenoic acid (DHA) concomitant with neoadjuvant chemotherapy versus neoadjuvant chemotherapy alone in the treatment of breast cancer (DHA WIN): protocol of a double-blind phase II randomised controlled trial [O] . Marnie Newell, John R Mackey, Gilbert Bigras, 2019

机译：比较二十二碳六碳六烯酸（DHA）与新辅助化疗与单纯新辅助化疗在乳腺癌治疗（DHA WIN）中的比较：一项双盲II期随机对照试验的方案
7. Comparing docosahexaenoic acid (DHA) concomitant with neoadjuvant chemotherapy versus neoadjuvant chemotherapy alone in the treatment of breast cancer (DHA WIN): protocol of a double-blind, phase II, randomised controlled trial [O] . Marnie Newell, John R Mackey, Gilbert Bigras, 2019

机译：比较Docosahexeno酸（DHA）伴随着Neoadjuvant化疗与Neoadjuvant化疗单独治疗乳腺癌（DHA Win）：双盲，II期，随机对照试验的协议

Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray-drying processing

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