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首页> 外文期刊>Food Chemistry >A comprehensive approach for the simultaneous analysis of all main water-soluble vitamins in multivitamin preparations by a stability-indicating HPLC-DAD method
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A comprehensive approach for the simultaneous analysis of all main water-soluble vitamins in multivitamin preparations by a stability-indicating HPLC-DAD method

机译：一种通过稳定性指示HPLC-DAD方法同时分析多种维生素制剂中所有主要水溶性维生素的综合方法

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摘要

A stability-indicating HPLC-DAD method for simultaneous determination of all nine main water-soluble vitamins, in addition to two commonly used vitamers, was developed and fully validated in analytical ranges, adjusted to their recommended dietary allowance values. An XSelect CSH C18 column with gradient elution using phosphate buffer and methanol was used for their optimal separation. The results from forced degradation studies along with peak purity tests and response ratios at dual wavelengths for the individual vitamins in all tested samples confirmed the method's stability-indicative nature. The complete developed methodology, including a single sample preparation for the vitamins simultaneous analysis, was applied to their assay in 13 commercial multivitamin preparations, revealing mostly higher amounts than the label claims. The developed method is applicable for stability testing, multivitamin products shelf-life determination as well as routine assay analysis of all water-soluble vitamins in their most common forms, including the analytically most demanding flavin mononucleotide.
机译：除了两种常用的维生素外，稳定性指示的HPLC-DAD方法，用于同时测定所有九种主要水溶性维生素，在分析范围内开发并完全验证，调整为其推荐的膳食津贴值。使用磷酸盐缓冲液和甲醇具有梯度洗脱的X选择CSH C18柱进行最佳分离。强制降解研究以及所有测试样品中各自维生素的双波长的峰纯度试验和响应比的结果证实了该方法的稳定性指示性质。完整的开发方法，包括对维生素同时分析的单一样品制备，在其测定中应用于13种商业多种维生素制剂，揭示大多数比标签权利要求更高。开发的方法适用于稳定性测试，多种维生素产品质子寿命确定以及所有水溶性维生素的常规测定分析，以其最常见的形式，包括分析最苛刻的黄蛋白单核苷酸。

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