Preparation, characterisation and activity of the inclusion complex of paeonol with β-cyclodextrin

Yuhsin Tsai; Hsieh-Ho Tsai; Chien-Pang Wu; Fuu-Jen Tsai

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Preparation, characterisation and activity of the inclusion complex of paeonol with β-cyclodextrin

机译：丹皮酚与β-环糊精的包合物的制备，表征及活性

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The inclusion complex of β-cyclodextrin (β-CD) and paeonol (2'-hydroxy-4'-methoxyacetophenone, PAE) was synthesised and characterised by thermal gravimetric analysis (TGA) and two-dimensional rotating frame spectroscopy (2D ROESY). The antioxidant activity and tyrosinase inhibition activity were also studied. The TGA results indicated that the thermal stability of PAE was improved when it was included with β-CD. Based on the 2D ROESY analysis, an inclusion structure of the PAE-β-CD complex was proposed, in which PAE penetrated β-CD in a tilted manner due to the interaction of intermolecular hydrogen bonds between PAE and β-CD. The complex of PAE with β-CD increased the antioxidant activity and tyrosinase-inhibiting activity of PAE.

机译：合成了β-环糊精（β-CD）和丹皮酚（2'-羟基-4'-甲氧基苯乙酮，PAE）的包合物，并通过热重分析（TGA）和二维旋转框架光谱法（2D ROESY）对其进行了表征。还研究了抗氧化活性和酪氨酸酶抑制活性。 TGA结果表明，当β-CD包含PAE时，PAE的热稳定性得到改善。基于二维ROESY分析，提出了PAE-β-CD复合物的夹杂结构，由于PAE和β-CD之间的分子间氢键相互作用，PAE以倾斜的方式穿透了β-CD。 PAE与β-CD的复合物增加了PAE的抗氧化活性和酪氨酸酶抑制活性。

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来源
《Food Chemistry》 |2010年第3期|837-841|共5页
作者
Yuhsin Tsai; Hsieh-Ho Tsai; Chien-Pang Wu; Fuu-Jen Tsai;
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作者单位

School of Chinese Medicine, China Medical University, Taichung, Taiwan;

Nano-Powder and Thin Film Technology Center, Industrial Technology Research Institute, Tainan, Taiwan;

Nano-Powder and Thin Film Technology Center, Industrial Technology Research Institute, Tainan, Taiwan;

School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan Department of Medical Genetics, Pediatrics and Medical Research, China Medical University Hospital, Taichung, Taiwan Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
paeonol; β-Cyclodextrin; ROESY; antioxidant activity; tyrosinase inhibition;

机译：丹皮酚β-环糊精;ES色抗氧化活性酪氨酸酶抑制;

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Preparation, characterisation and activity of the inclusion complex of paeonol with β-cyclodextrin

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