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首页> 外文期刊>Food research international >A metabolomics footprint approach to understanding the benefits of synbiotics in functional foods and dietary therapeutics for health, communicable and non-communicable diseases
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A metabolomics footprint approach to understanding the benefits of synbiotics in functional foods and dietary therapeutics for health, communicable and non-communicable diseases

机译：代谢组学足迹方法，用于了解功能食品和饮食疗法中的合生素对健康，传染性和非传染性疾病的益处

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摘要

Gut microbiota have been shown to affect various cellular and host response elements such as immunological, neurological, energy, storage, etc. In recent years, this has led to rapid expansion in dietary products containing probiotics, prebiotics and combination thereof in synbiotics. While benefits of consuming functional foods derived from probiotics strains have been demonstrated for various metabolites, a detailed analysis of the biochemical footprints and their benefits remain under-studied. Herein, using a combination of NMR metabolomics, microbial techniques and cell-culture assays, we have characterized metabolite profiles of probiotic viz. Lactobacillus delbruekii ATCC 9649, Lactobacillus casei ATCC 335, Lactobacillus plantarum NRC 716 and Bacillus coagulans ATCC 12425 cultures in fermented milk. We identified predominance of sugars, small chain fatty acids, organic acids and branched chain amino acids from natural abundance C-13 NMR studies. Additionally, we identified myriad metabolites and their respective pathways using H-1 NMR spectroscopy. Based on our findings, synbiotic fermented dairy products were customized with co-cultures and complemented with pro- and prebiotics. Furthermore, we demonstrate epithelial cell interaction and anti-microbial activity of L. plantarum based ferment against a range of bacterial pathogens highlighting possible biochemical mechanisms for anti-microbial activity, quorum sensing, gut colonization and other beneficial factors that may be crucial. Furthermore, we propose plausible explanation against non-communicable diseases such as tumor-inhibitory, anti-proliferative and pro-apoptotic effects which has direct implications for dietary therapeutics.
机译：肠道菌群已显示影响各种细胞和宿主反应成分，例如免疫，神经，能量，贮藏等。近年来，这导致含益生菌，益生元及其在合生元中的组合的饮食产品迅速膨胀。尽管食用益生菌菌株的功能性食品对各种代谢物的益处已得到证实，但对生化足迹及其益处的详细分析仍未得到充分研究。在这里，结合使用NMR代谢组学，微生物技术和细胞培养测定，我们表征了益生菌的代谢物特征。发酵乳中的德氏乳杆菌ATCC 9649，干酪乳杆菌ATCC 335，植物乳杆菌NRC 716和凝结芽胞杆菌ATCC 12425培养物。我们通过自然丰度C-13 NMR研究确定了糖，小链脂肪酸，有机酸和支链氨基酸的优势。此外，我们使用H-1 NMR光谱鉴定了多种代谢物及其各自的途径。根据我们的发现，共生发酵乳制品通过共培养进行了定制，并辅以益生元和益生元。此外，我们证明了基于植物乳杆菌的发酵液对一系列细菌病原体的上皮细胞相互作用和抗微生物活性，突出了抗微生物活性，群体感应，肠道定植和其他可能至关重要的有益因素的可能生化机制。此外，我们提出了针对非传染性疾病的合理解释，例如肿瘤抑制，抗增殖和促凋亡作用，这些对饮食疗法具有直接影响。

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  • 来源
    《Food research international》 |2020年第2期|108679.1-108679.10|共10页
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  • 作者单位

    Indian Inst Sci Educ & Res Bhopal Dept Chem Acad Bldg 2 Bhopal 462066 Madhya Pradesh India|Cuukky Nat Sci Pvt Ltd Padam Housing Soc 7 Padma Bldg Pune 411037 Maharashtra India;

    Indian Inst Sci Educ & Res Bhopal Dept Chem Acad Bldg 2 Bhopal 462066 Madhya Pradesh India;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    NMR metabolomics; Gut flora; Synbiotics; Probiotics; Biochemical profiling; Antibiosis;

    机译：NMR代谢组学;肠道菌群合生素;益生菌;生化分析;抗菌剂;

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