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首页> 外文期刊>Food research international >Comparative effects of safflower oil and perilla oil on serum and hepatic lipid levels, fatty acid compositions of serum and hepatic phospholipids, and hepatic mRNA expressions of 3-hydroxy-3- methylglutaryl CoA reductase, LDL receptor, and cholester
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Comparative effects of safflower oil and perilla oil on serum and hepatic lipid levels, fatty acid compositions of serum and hepatic phospholipids, and hepatic mRNA expressions of 3-hydroxy-3- methylglutaryl CoA reductase, LDL receptor, and cholester

机译：红花油和紫苏油对血清和肝脂质水平，血清和肝磷脂的脂肪酸组成以及3-羟基-3-甲基戊二酰辅酶A还原酶，LDL受体和胆固醇的肝mRNA表达的比较作用

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摘要

Male Wistar rats, 4 and 33 weeks of age, were fed the diets containing saffiower oil (SO-diet, 77.3/100 linoleic acid) or perilla oil (PO-diet, 58.4/100 α-linolenic acid) for 7 days. Serum total cholesterol was lower on the PO-diet in both ages. On the other hand hepatic cholesterol and phospholipids were significantly higher in the PO group than in the SO group of the adult rats. Tlie PO group showed significantly lower 20:4 n-6 but higher l8:2 n-6 in hepatic phosphatidylcholine compared with the SO group in both ages. Hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA was significantly lower on the PO-diet than on the SO-diet irrespective of age. The present results show that a-linolenic acid has a higher hypocholesterolemic ability than linoleic acid in rats irrespective of age and these fatty acids behaved differently in affecting hepatic mRNA expressions of HMG- CoA reductase, LDL receptor, and cholesterol 7a-hydroxylase.
机译：给4和33周龄的雄性Wistar大鼠喂食含红花油（SO饮食，77.3 / 100亚油酸）或紫苏油（PO饮食，58.4 / 100α-亚麻酸）的饮食，持续7天。在两个年龄段，PO饮食中的血清总胆固醇均较低。另一方面，成年大鼠的PO组的肝胆固醇和磷脂水平明显高于SO组。与SO组相比，Tlie PO组的肝磷脂酰胆碱组的20：4 n-6显着降低，而18：2 n-6显着高于两个年龄组。肝3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶mRNA在PO饮食上显着低于SO饮食，而与年龄无关。目前的结果表明，无论年龄大小，α-亚麻酸在大鼠中均具有比亚油酸更高的降胆固醇能力，并且这些脂肪酸在影响HMG-CoA还原酶，LDL受体和胆固醇7a-羟化酶的肝mRNA表达中具有不同的表现。

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