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首页> 外文期刊>Food science and biotechnology >Analysis of Chemical Interactions of (-)-Epigallocatechin-3-gallate, a Major Green Tea Polyphenol, with Commonly-consumed Over-the- counter Drugs
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Analysis of Chemical Interactions of (-)-Epigallocatechin-3-gallate, a Major Green Tea Polyphenol, with Commonly-consumed Over-the- counter Drugs

机译：主要绿茶多酚（-）-表没食子儿茶素-3-没食子酸酯与常用的非处方药的化学相互作用的分析

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摘要

In the present study, changes in chemical stabilities were investigated after incubation of commonly-consumed over-the-counter (OTC) drugs with (-)-epigallocatechin-3-gallate (EGCG), a major green tea polyphenol. Stability of EGCG was significantly increased in the presence of millimolar levels of acetylsalicylic acid (Asp); EGCG stability was not affected by ibuprofen and acetaminophen (AAP). Stability of AAP was not altered in the presence of EGCG during 24 hr-incubation at pH 2.0, 7.4, and 8.0. Asp stability and formation of salicylic acid were not affected by EGCG at pH 2.0 either. The present study may provide basic information for chemical interactions between dietary polyphenols and OTC drugs.
机译：在本研究中，将常用的非处方药（OTC）与主要的绿茶多酚（-）-表没食子儿茶素-3-没食子酸酯（EGCG）孵育后，研究了化学稳定性的变化。毫摩尔水平的乙酰水杨酸（Asp）存在时，EGCG的稳定性显着提高； EGCG的稳定性不受布洛芬和对乙酰氨基酚（AAP）的影响。在pH 2.0、7.4和8.0孵育24小时期间，在EGCG存在的情况下AAP的稳定性没有改变。在pH 2.0时，EGCG也不会影响asp的稳定性和水杨酸的形成。本研究可为饮食中多酚与非处方药之间的化学相互作用提供基本信息。

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