Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

Rieko Nakata; Yoshie Takizawa; Ayako Takai; Hiroyasu Inoue

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Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

机译：通过PPAR激活和COX-2表达抑制评估食品衍生的功能成分

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The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor family. They are considered molecular targets for the prevention of lifestyle-related diseases and are involved in the control of cyclooxygenase (COX)-2 expression. COX-2, the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis, and its expression is partly controlled by PPAR. We have identified several natural chemicals, such as resveratrol, that activate PPARs and suppress COX-2 expression. In this review, we provide an evaluation of food-derived functional ingredients that target PPARs and COX-2.

机译：过氧化物酶体增殖物激活受体（PPAR）是属于核受体家族的依赖配体的转录因子。它们被认为是预防与生活方式有关的疾病的分子靶标，并参与环氧合酶（COX）-2表达的控制。 COX-2是前列腺素生物合成中的限速酶，在炎症和循环稳态中起关键作用，其表达部分受PPAR控制。我们已经鉴定出几种天然化学物质，例如白藜芦醇，它们可以激活PPARs并抑制COX-2的表达。在这篇综述中，我们提供了针对PPAR和COX-2的食品衍生功能成分的评估。

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来源
《Food science and technology research》 |2013年第3期|339-345|共7页
作者
Rieko Nakata; Yoshie Takizawa; Ayako Takai; Hiroyasu Inoue;
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作者单位

Department of Food Science and Nutrition, Nara Women's University, Kitauoya-nishimachi, Nara 630-8506, Japan;

Department of Food Science and Nutrition, Nara Women's University, Kitauoya-nishimachi, Nara 630-8506, Japan;

Department of Food Science and Nutrition, Nara Women's University, Kitauoya-nishimachi, Nara 630-8506, Japan;

Department of Food Science and Nutrition, Nara Women's University, Kitauoya-nishimachi, Nara 630-8506, Japan;

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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 eng
中图分类
关键词
PPAR; COX-2; resveratrol; essential oil; anti-lifestyle-related disease;

机译：PPAR;COX-2;白藜芦醇香精油;抗生活方式相关疾病;

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1. Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR gamma agonists: evidence for disparate functional effects which are independent of NF-kappa B and PPAR-gamma [J] . Patel KM, Wright KL, Whittaker P, Cellular Signalling . 2005,第9期

机译：结构不同的PPARγ激动剂对A549气道上皮细胞中COX-2表达的差异调节：独立于NF-κB和PPAR-γ的不同功能作用的证据
2. Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE(2) production in HaCaT cells through PPAR-gamma activation [J] . Yoshizaki Norihiro, Fujii Takahiro, Masaki Hitoshi, Experimental dermatology . 2014,第Suppla1期

机译：桔皮提取物，含有高水平的聚甲氧基类黄酮，通过PPAR-γ激活抑制HaCaT细胞中UVB诱导的COX-2表达和PGE（2）的产生
3. The involvement of the CD40-CD40L pathway in activated platelet-induced changes in HUVEC COX-2 and PPARα expression. [J] . Yan-qing Wu, Xiao-shu Chen, Jun-bing Chai Inflammation . 2012,第3期

机译：CD40-CD40L途径参与活化的血小板诱导的HUVEC COX-2和PPARα表达的变化。
4. The functional efficiency of lipogenic and cholesterogenic gene expression in normal miceand in mice lacking the peroxisomal proliferator-activated receptor-alpha (PPAR-α) [C] . Geoffrey F. Gibbons, Dilip Patel, David Wiggins, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：缺乏过氧化合物酶体增殖物激活受体-α（PPAR-α）正常MiCeand中脂肪生成和胆固基因表达的功能效率
5. PPAR-gamma ligands and adipocytes regulate expression of the plasminogen activator system in breast cancer. [D] . Carter, Jennifer Carol. 2009

机译：PPAR-γ配体和脂肪细胞可调节乳腺癌中纤溶酶原激活剂系统的表达。
6. Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy [O] . Roi Cal, Heidi Davis, Alish Kerr, 2020

机译：食物衍生的功能成分的临床前评价来解决骨骼肌萎缩
7. Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression [O] . Rieko NAKATA, Yoshie TAKIZAWA, Ayako TAKAI, 2013

机译：根据PPAR激活和抑制COX-2表达的激活评价食品衍生的功能成分

Evaluation of Food-derived Functional Ingredients According to Activation of PPAR and Suppression of COX-2 Expression

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