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首页> 外文期刊>Food science and technology research >Angiotensin-Converting Enzyme-Inhibitory Peptides Isolated from Pepsin Hydrolyzate of Apios americana Tuber and Their Hypotensive Effects in Spontaneously Hypertensive Rats
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Angiotensin-Converting Enzyme-Inhibitory Peptides Isolated from Pepsin Hydrolyzate of Apios americana Tuber and Their Hypotensive Effects in Spontaneously Hypertensive Rats

机译：自发Apios块茎胃蛋白酶水解产物分离的血管紧张素转换酶抑制肽及其对自发性高血压大鼠的降压作用

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摘要

With the aim of elucidating the hypotensive effects of Apios americana Medikus tuber, active ingredients with angiotensin-converting enzyme (ACE)-inhibitory activity were identified and their hypotensive effects in spontaneously hypertensive rats (SHR) were investigated. From a pepsin digest of A. americana showing strong activity, two ACE-inhibitory peptides were isolated and identified as YRLPNL and YQLP. Although the ACE-inhibitory activity of YQLP was weak, YRLPNL showed strong ACE-inhibitory activity (IC_(50) value 7.7 nM) equal to those of lisinopril and captopril. After a single oral administration of YRLPNL, SHR showed a significant decrease in blood pressure. These results suggest that YRLPNL, isolated from A. Americana, is a hypotensive peptide having ACE-inhibitory activity. This is the first report of a food peptide having ACE-inhibitory activity equal to that of Pharmaceuticals.
机译：为了阐明Apios americana Medikus块茎的降压作用，鉴定了具有血管紧张素转化酶（ACE）抑制活性的活性成分，并研究了其对自发性高血压大鼠（SHR）的降压作用。从表现出强活性的美洲曲霉的胃蛋白酶消化物中，分离出两种ACE抑制肽，并鉴定为YRLPNL和YQLP。尽管YQLP的ACE抑制活性较弱，但YRLPNL却显示出与赖诺普利和卡托普利相同的强ACE抑制活性（IC_（50）值为7.7 nM）。单次口服YRLPNL后，SHR血压显着下降。这些结果表明，从美洲曲霉分离的YRLPNL是具有ACE抑制活性的降血压肽。这是具有与药物相同的ACE抑制活性的食物肽的首次报道。

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  • 来源
    《Food science and technology research》 |2013年第3期|399-407|共9页
  • 作者

    Shusuke Kuramoto; Gyoshin Kaneyoshi; Yae Morinaga; Hajime Matsue; Kunihisa Iwai;

  • 作者单位

    Department of Life Sciences, Graduate School of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, Aomori 030-8505, Japan;

    Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, Aomori 030-8505, Japan;

    Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, Aomori 030-8505, Japan;

    Department of Life Sciences, Graduate School of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, Aomori 030-8505, Japan;

    Department of Life Sciences, Graduate School of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, Aomori 030-8505, Japan,Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, Aomori 030-8505, Japan;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Apios americana; ACE inhibition; hypotensive effect; peptide; SHR;

    机译：美洲Apios;ACE抑制;降压作用肽SHR;

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