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首页> 外文期刊>Food science and technology research >Preventive Effects of Black Soybean Seed Coat Polyphenols against DNA Damage in Salmonella typhimurium
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Preventive Effects of Black Soybean Seed Coat Polyphenols against DNA Damage in Salmonella typhimurium

机译：黑大豆种皮多酚对鼠伤寒沙门氏菌DNA损伤的预防作用

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摘要

Black soybean seed coat is a rich source of polyphenols reported to have various physiological functions. The present study investigated the potential protective effects of polyphenolic extracts from black soybean seed coat on mutagen-induced DNA damage in Salmonella typhimurium. Results from the Ames test using Salmonella stains revealed that black soybean seed coat extract (BE) at 5000 μg/plate showed neither mutagenicity nor cytotoxicity. In contrast, BE, its component cyanidin 3-glucoside (C3G), or procyanidin-rich BE (PC-rich BE) dose-dependently inhibited B(a)P- and 4NQO-induced mutagenesis in the rank order: C3G > BE > PC-rich BE. At 5 μM/plate, C3G and procyanidins, the major polyphenols in BE, inhibited B(a)P-induced mutagenesis in TA 98 and TA 100 by 28 - 59%. They also inhibited 4NQO-induced mutagenesis by 26 - 56%. Collectively, we found that C3G and procyanidins, which are the main active compounds in BE, effectively protected against DNA mutagenic damage in Salmonella typhimurium.
机译：黑大豆种皮是据称具有多种生理功能的多酚的丰富来源。本研究调查了黑大豆种皮中多酚提取物对诱变剂诱导鼠伤寒沙门氏菌DNA损伤的潜在保护作用。使用沙门氏菌染色剂进行的Ames试验结果表明，每板5000μg的黑大豆种皮提取物（BE）既没有诱变性，也没有细胞毒性。相比之下，BE，其组分花青素3-葡萄糖苷（C3G）或富含原花青素的BE（富含PC的BE）剂量依赖性地抑制了B（a）P和4NQO诱导的诱变，其排列顺序为：C3G> BE>富含PC的BE。在5μM/板时，BE中的主要多酚C3G和原花青素将B（a）P诱导的TA 98和TA 100诱变抑制了28-59％。他们还抑制了4NQO诱导的诱变26-56％。总体而言，我们发现C3G和原花青素是BE中的主要活性化合物，可以有效地保护鼠伤寒沙门氏菌免受DNA诱变损害。

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  • 来源
    《Food science and technology research》 |2013年第4期|685-690|共6页
  • 作者

    Tianshun Zhang; Kyuichi KAWABATA; Rei Kitano; Hitoshi Ashida;

  • 作者单位

    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan;

    Organization of Advanced Science and Technology, Kobe University, Kobe 657-8501, Japan,Department of Bioscience, Fukui Prefectural University, Fukui 910-1195, Japan;

    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan;

    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    black soybean seed coat extract; procyanidins; cyanidin 3-glucoside; DNA damage; Ames test;

    机译：黑大豆种皮提取物;原花青素;花青素3-葡萄糖苷;DNA损伤;艾姆斯测试;

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