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Organ- und funktionserhaltende Therapie von Kopf-Hals-Tumoren

机译:头颈部肿瘤的器官和功能保留疗法

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摘要

Head and neck squamous cell carcinoma (HNSCC) are still a frequent tumor entity worldwide. The prevalence of human papillomavirus (HPV)-associated tumors is increasing; therefore treatment schedules are shifting to more specific therapies according to tumor biology. Independent of the HPV status a variety of treatment options are currently available. Various criteria, e.g. tumor stage, comorbidities, age and socioeconomic factors must be taken into consideration when planning therapy. Besides local tumor control, the goal is always organ and function preservation. This review gives an overview of present therapeutic options in HNSCC. One focus is an update of possibilities in robot-assisted head and neck surgery. Apart from the non-surgical approaches, the indications and limitations of induction chemotherapy, concomitant radiochemotherapy and radiotherapy alone will be discussed.
机译:头颈部鳞状细胞癌(HNSCC)仍然是世界范围内常见的肿瘤实体。人类乳头瘤病毒(HPV)相关肿瘤的患病率正在上升;因此,根据肿瘤生物学,治疗方案正在转向更具体的治疗方法。与HPV状态无关,目前有多种治疗选择。各种标准,例如计划治疗时必须考虑肿瘤的分期,合并症,年龄和社会经济因素。除了局部肿瘤控制之外,目标始终是器官和功能的保存。这篇综述概述了HNSCC中目前的治疗选择。一个重点是机器人辅助头颈部手术的可能性的更新。除了非手术方法外,还将讨论诱导化疗,伴随放疗和仅放疗的适应症和局限性。

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