THE CLASTOGENIC EFFECTS OF BENZOYL PEROXIDE (BPO) IN HUMAN LYMPHOCYTE CULTURES

Mediha Canbek; Halime OEnuer; Berrin Ayaz Tueylue; Derya UEstuener

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THE CLASTOGENIC EFFECTS OF BENZOYL PEROXIDE (BPO) IN HUMAN LYMPHOCYTE CULTURES

机译：过氧化苯甲酰（BPO）在人类淋巴细胞培养中的致死作用

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Benzoyl peroxide (BPO) is one of the important oxi-dant compounds used as a free radical initiator in plastic production, as a bleaching agent in food and as a drug compound of acne treatment in cosmetic and pharmaceu-ticals industries. It is a progression agent in mouse skin carcinogenesis because it has tumor promoter activity and also strong cytotoxic activity. In this study, we have investigated the clastogenic effects of BPO with CBMN assay in human blood lymphocyte cultures. BPO at final concentrations of 10~(-5) M, 10~(-6)M, and 10~(-7)M was tested in peripheral bloods obtained from eight healthy male and eight female donors. According to data, the frequency of cells with mi-cronuclei showed a statistically significant dose increase in a dependent manner compared with negative controls. Comparing the two donor groups, the differences in the mean counts were not significant. Increasing micronucleus rates showed that BPO could have clastogenic effect in human lymphocytes.

机译：过氧化苯甲酰（BPO）是一种重要的氧化剂化合物，在塑料生产中用作自由基引发剂，在食品中用作漂白剂，在化妆品和制药行业中用作痤疮治疗的药物化合物。它是小鼠皮肤癌变的进展剂，因为它具有肿瘤启动子活性，还具有很强的细胞毒性活性。在这项研究中，我们研究了CPON检测在人血淋巴细胞培养中对BPO的杀乳作用。在从八位健康男性和八位女性供体获得的外周血中测试了最终浓度为10〜（-5）M，10〜（-6）M和10〜（-7）M的BPO。根据数据，与阴性对照相比，具有微核细胞的细胞频率以依赖性方式显示出统计学上显着的剂量增加。比较两个供体组，平均计数的差异不显着。微核率的增加表明BPO可能在人类淋巴细胞中产生致死作用。

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来源
《Fresenius Environmental Bulletin》 |2010年第4a期|p.730-734|共5页
作者
Mediha Canbek; Halime OEnuer; Berrin Ayaz Tueylue; Derya UEstuener;
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作者单位

Department of Biology, Faculty of Art and Sciences, Eskisehir Osmangazi University, Turkey;

Department of Medical Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey;

Department of Biology, Faculty of Sciences, Anadolu University, Eskisehir, Turkey;

rnDepartment of Medical Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey;

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正文语种 eng
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benzoyl peroxide; CBMN assay; clastogenicity; micronuclei; human lymphocytes;

机译：过氧化苯甲酰;CBMN测定;致裂性微核人淋巴细胞;

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机译：双酚A对人类培养淋巴细胞的抗植物学作用
2. Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes [J] . Djelic N., Djelic D., Spremo-Potparevic B., Genetics and molecular biology: publication of the Sociedade Brasileira de Genetica . 2007,第4期

机译：L-甲状腺素对全血培养的人淋巴细胞缺乏致死作用
3. Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes [J] . Biljana Markovic, Biljana Spremo-potparevic, Dijana Djelic, Genetics and molecular biology: publication of the Sociedade Brasileira de Genetica . 2007,第4期

机译：L-甲状腺素对全血培养的人淋巴细胞缺乏致死作用
4. EFFECTS OF CARVACROL ON SISTER CHROMATID EXCHANGES IN HUMAN LYMPHOCYTE CULTURES [C] . EVRIM IPEK, BERRIN AYAZ TUYLU, HULYA ZEYTIMOGLU Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：Carvacrol对人淋巴细胞培养症症患者染色体交换的影响
5. The cell cycle phase specificity of DNA damage induced by radiation, peroxide and chemotherapeutic drugs targeting topoisomerase II, and CD4 and CD8 receptor expression on apoptotic human lymphocytes. [D] . Potter, Alan J. 2003

机译：靶向拓扑异构酶II的放射线，过氧化物和化学治疗药物诱导的DNA损伤的细胞周期相位特异性，以及凋亡的人类淋巴细胞上CD4和CD8受体的表达。
6. Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation [O] . 1978

机译：通过将淋巴细胞与肿瘤来源或病毒转化的细胞培养来诱导抗病毒活性。鉴定抗病毒活性作为干扰素并鉴定人类效应淋巴细胞亚群
7. Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes [O] . Ninoslav Djelic, Dijana Djelic, Biljana Spremo-Potparevic, 2007

机译：L-甲状腺素对全血培养的人淋巴细胞缺乏致死作用
8. Initial Submission: in Vitro Assessment of Hcfc 123 Vp Clastogenic Activity in Cultured Human Lymphocytes with Cover Letter dated 082492. [R] . 1992

机译：初步提交：体外评估培养的人淋巴细胞中Hcfc 123 Vp的致死活性，封面信函日期为082492。

THE CLASTOGENIC EFFECTS OF BENZOYL PEROXIDE (BPO) IN HUMAN LYMPHOCYTE CULTURES

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