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首页> 外文期刊>Genes & Genomics >Transmission ratio distortion in an interspecific cross between Fusarium circinatum and Fusarium subglutinans
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Transmission ratio distortion in an interspecific cross between Fusarium circinatum and Fusarium subglutinans

机译：圆镰刀菌和次生镰刀菌种间杂交的传递比畸变

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Previously, an interspecific cross between Fusarium circinatum and Fusarium subglutinans was used to generate a genetic linkage map. A ca. 55 % of genotyped markers displayed transmission ratio distortion (TRD) that demonstrated a genome-wide distribution. The working hypothesis for this study was that TRD would be non-randomly distributed throughout the genetic linkage map. This would indicate the presence of distorting loci. Using a genome-wide threshold of α = 0.01, 79 markers displaying TRD were distributed on all 12 linkage groups (LGs). Eleven putative transmission ratio distortion loci (TRDLs), spanning eight LGs, were identified in regions containing three or more adjacent markers displaying distortion. No epistatic interactions were observed between these TRDLs. Thus, it is uncertain whether the genome-wide TRD was due to linkage between markers and genomic regions causing distortion. The parental origins of markers followed a non-random distribution throughout the linkage map, with LGs containing stretches of markers originating from only one parent. Thus, due to the nature of the interspecific cross, the current hypothesis to explain these observations is that the observed genome-wide segregation was caused by the high level of genomic divergence between the parental isolates. Therefore, homologous chromosomes do not align properly during meiosis, resulting in aberrant transmission of markers. This also explains previous observations of the preferential transmission of F. subglutinans alleles to the F1 progeny.
机译：以前，使用镰刀镰刀菌（Fusarium circinatum）和谷氨酸镰刀菌（Fusarium subglutinans）之间的种间杂交来生成遗传连锁图。大约55％的基因分型标记显示出传输率失真（TRD），证明了全基因组分布。这项研究的有效假设是TRD将在整个遗传连锁图中非随机分布。这将表明存在扭曲的基因座。使用全基因组阈值α= 0.01，在所有12个连锁组（LGs）上分布了79个显示TRD的标记。在包含三个或更多显示失真的相邻标记的区域中，确定了跨越八个LG的11个推定的传输比失真基因座（TRDL）。在这些TRDL之间未观察到上位性相互作用。因此，尚不确定全基因组范围的TRD是否是由于标记和基因组区域之间的连锁而引起的。标记的亲本起源在整个连锁图中都遵循非随机分布，其中LG包含仅来自一个亲本的一系列标记。因此，由于种间杂交的性质，目前解释这些发现的假设是观察到的全基因组分离是由亲本分离株之间高水平的基因组差异引起的。因此，在减数分裂过程中同源染色体不能正确对齐，从而导致标记的异常传递。这也解释了以前的观察结果，即次谷氨酸镰刀菌等位基因优先传递至F1后代。

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